Results 121 to 130 of about 138,513 (347)

Astrocyte Enrichment of 3D Cortical Constructs Enhances Brain Repair

Advanced Science, EarlyView.
This study highlights the role of astrocytes in supporting neural progenitor cell survival and differentiation after traumatic brain injury. Astrocytes enhanced neuronal differentiation, improved cell survival in co‐cultures, and promoted integration of microfluidics‐based implants with host tissue following implantation. Additionally, increased axonal
Elisa M. Cruz, Luana C. Soares, Gretchen Greene, Fernando Messore, Mohammed Abuelem, Mingyu Li, Caroline Andersen, Mirriam Domocos, Elisa Vitiello, Rabeah Abdul Razak, Marlene Lawston, Gabriel Moser, Talia Vasaturo‐Kolodner, Mona Barkat, Roslyn M. Bill, Edward Mann, Linna Zhou, Mootaz M. Salman, Hagan Bayley, Zoltán Molnár, Francis G. Szele   +20 more
wiley   +1 more source

Calculation of Temperature Fields in a Lithium Ceramic Pebble Bed during Reactor Irradiation in a Vacuum. [PDF]

Materials (Basel), 2023
Chikhray Y, Kulsartov T, Zaurbekova Z, Kenzhina I, Samarkhanov K.   +4 more
europepmc   +1 more source

Remimazolam Ameliorates Autistic‐Like Behaviors via Suppression of Ferroptosis in VTA Dopaminergic Neurons in a Mouse Model of ASD

Advanced Science, EarlyView.
The ultra‐short‐acting sedative remimazolam has a sustained therapeutic effect on the core symptoms of VPA‐exposed mice. Remimazolam, a GABA agonist, exerts its therapeutic effects by protecting dopamine neurons in the VTA of VPA‐exposed mice. Meanwhile, ferroptosis is the critical mechanism by which remimazolam protects VTA dopaminergic neurons and ...
Yuxin Zhang, Jianwei Lin, Chaoyang Tong, Xin Fu, Mengqin Shan, Yue Huang, Kan Zhang, Jijian Zheng   +7 more
wiley   +1 more source

Development of water-cooled cylindrical blanket in JA DEMO

Nuclear Fusion
The concept of the tritium breeding blanket for Japan’s DEMOnstration fusion reactor (JA DEMO) has been developed with pressure tightness against in-box loss-of-coolant accidents based on a water-cooled solid breeder concept.
Someya Youji, Tanigawa Hiroyasu, Sakamoto Yoshiteru, the Joint Special Design Team for Fusion DEMO   +3 more
doaj   +1 more source

Tim1 Deficiency Mediates Gestational Hyperglycemia‐Related Syncytiotrophoblast Dysfunction and Fetal Growth Restriction

Advanced Science, EarlyView.
Hyperglycemia during pregnancy impairs the fusion of trophoblast cells into syncytiotrophoblasts, leading to fetal growth restriction. This impaired fusion is mediated by Tim1 downregulation via hyperglycemia‐induced ROS. Antioxidant therapy during pregnancy promotes syncytiotrophoblast formation by upregulating Tim1 expression, thus alleviating fetal ...
Junsen She, Rui Liu, Chen Fang, Shuyu Zhang, Yizhi Hu, Fei Guo, Yuhang Long, Mengzhen Ding, Haiyan Wu, Bokang Zhou, Zexin Yang, Ying Jiang, Jianzhong Sheng, Ling Gao, Hefeng Huang   +14 more
wiley   +1 more source

Corrosive behavior of structural F82H RAFM steel by LTZO ceramic breeder pebbles

Nuclear Materials and Energy
In this study, corrosion behavior of F82H reduced activation ferritic/martensitic steel (RAFM) by LTZO (Li2+xTiO3+y solid solution with 20 wt% Li2ZrO3) ceramic breeder pebbles was investigated at 773–998 K in an inert sweep gas condition (Ar + 0.1 % H2).
Kosuke Kataoka, Keisuke Mukai, Juro Yagi, Motoki Nakajima, Jae-Hwan Kim, Takashi Nozawa   +5 more
doaj   +1 more source

Testicular mRNA‐LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders

Advanced Science, EarlyView.
In the current study, we developed a novel therapy for genetic spermatogenic disorders. It was revealed that in vivo delivery of mRNA LNP3 could restore spermatogenesis in Msh5D486Y/D486Y and Maps KO mouse models with meiotic arrest. Notably, the offspring without genomic integration was born using ICSI derived from the rescue of Msh5D486Y/D486Y mouse ...
Chenwang Zhang, Nan Liang, Wenbo Li, Shuai Xu, Peng Li, Wanze Ni, Na Li, Sha Han, Ningjing Ou, Haowei Bai, Yuxiang Zhang, Furong Bai, Yifan Sun, Dewei Qian, Xinjie Bu, Erlei Zhi, Ruhui Tian, Yuhua Huang, Jingpeng Zhao, Fujun Zhao, Hao Chen, Zheng Li, Chencheng Yao   +22 more
wiley   +1 more source

Comparative analysis of gas release from biphasic lithium ceramics pebble beds of various pebbles sizes and content under neutron irradiation conditions

Nuclear Materials and Energy
This paper presents the results of 4 reactor campaigns on the irradiation of biphasic lithium ceramics containing different ratios of lithium orthosilicate (LOS) and lithium metatitanate (LMT) components (25 and 35 mol% LMT in LOS). The size distribution
Timur Kulsartov, Zhanna Zaurbekova, Regina Knitter, Inesh Kenzhina, Yevgen Chikhray, Asset Shaimerdenov, Saulet Askerbekov, Gunta Kizane, Alexandr Yelishenkov, Timur Zholdybayev   +9 more
doaj   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

The IFMIF-DONES Irradiation Modules

Nuclear Fusion
The IFMIF-DONES Irradiation Modules consist of a set of systems designed to be tested in the IFMIF-DONES facility and which are thought to produce, in the future, an extensive, qualified and unique set of fusion-like irradiated experimental data ...
F. Arbeiter, U. Wiącek, B. Brañas, S. Gordeev, A. Kupferschmitt, Y. Qiu, A. Serikov, G. Zhou, J. Kotula, F. Arranz, F. Mota, M.I. Ortiz, D. Rapisarda, P. Araya, S. Becerril, T. Dézsi, J. Castellanos, A. Ibarra, the Eurofusion WPENS Team   +18 more
doaj   +1 more source