Results 111 to 120 of about 9,751 (308)

Single‐Cell Transcriptomics Reveals FLS2‐Dependent Hypoxia Signaling and ERF13‐Mediated Transcription During flg22‐Triggered Immunity

Advanced Science, EarlyView.
This study employs sc‐RNA sequencing, genetics, and phenotyping to systematically map the cell‐type‐specific immune responses triggered by flg22. It reveals FLS2‐dependent transcriptional reprogramming in epidermal and mesophyll cells, and uncovers crosstalk between immune and hypoxia signaling pathways.
Yaping Zhou, Aizhi Qin, Mengfan Li, Qianli Zhao, Luyao Kong, Lulu Yan, Chunyang Li, Hao Liu, Yinpeng Zhang, Jiani Long, Mengyu Liao, Mengmeng Zhou, Xiaoli Fan, Baozhen Wang, Wenxuan Kang, Shui Wang, Zhixin Liu, Xuwu Sun   +17 more
wiley   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Development of water-cooled cylindrical blanket in JA DEMO

Nuclear Fusion
The concept of the tritium breeding blanket for Japan’s DEMOnstration fusion reactor (JA DEMO) has been developed with pressure tightness against in-box loss-of-coolant accidents based on a water-cooled solid breeder concept.
Someya Youji, Tanigawa Hiroyasu, Sakamoto Yoshiteru, the Joint Special Design Team for Fusion DEMO   +3 more
doaj   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Corrosive behavior of structural F82H RAFM steel by LTZO ceramic breeder pebbles

Nuclear Materials and Energy
In this study, corrosion behavior of F82H reduced activation ferritic/martensitic steel (RAFM) by LTZO (Li2+xTiO3+y solid solution with 20 wt% Li2ZrO3) ceramic breeder pebbles was investigated at 773–998 K in an inert sweep gas condition (Ar + 0.1 % H2).
Kosuke Kataoka, Keisuke Mukai, Juro Yagi, Motoki Nakajima, Jae-Hwan Kim, Takashi Nozawa   +5 more
doaj   +1 more source

BLADE‐ON‐PETIOLE Genes Enable Genetic Bottleneck Mitigation Through Cross‐Species Repurposing of Floral Persistence Traits

Advanced Science, EarlyView.
This study shows that BLADE‐ON‐PETIOLE (BOP) proteins regulate floral abscission and senescence in tomato by interacting with TFAM1 to form transcriptional condensates controlling the ARABIDOPSIS THALIANA HOMEOBOX GENE 1 (ATH1)‐mediated abscission pathway.
Nan Xiao, Qianwen Lyu, Tinghao Zhang, Yupan Zou, Yue Xie, Dandan Yang, Cao Xu, Xiaozhen Huang   +7 more
wiley   +1 more source

Comparative analysis of gas release from biphasic lithium ceramics pebble beds of various pebbles sizes and content under neutron irradiation conditions

Nuclear Materials and Energy
This paper presents the results of 4 reactor campaigns on the irradiation of biphasic lithium ceramics containing different ratios of lithium orthosilicate (LOS) and lithium metatitanate (LMT) components (25 and 35 mol% LMT in LOS). The size distribution
Timur Kulsartov, Zhanna Zaurbekova, Regina Knitter, Inesh Kenzhina, Yevgen Chikhray, Asset Shaimerdenov, Saulet Askerbekov, Gunta Kizane, Alexandr Yelishenkov, Timur Zholdybayev   +9 more
doaj   +1 more source

Comparative evaluation of solar, fission, fusion, and fossil energy resources, part 3 [PDF]

The role of nuclear fission reactors in becoming an important power source in the world is discussed. The supply of fissile nuclear fuel will be severely depleted by the year 2000. With breeder reactors the world supply of uranium could last thousands of
Clement, J. D., Reupke, W. A.
core   +1 more source

Diversity Patterns of Domestic Herbivore Viruses in China Reveal Transmission Dynamics with Disease Management Implications

Advanced Science, EarlyView.
This study performs pan‐viromic profiling of 14,529 samples from 5,710 domestic herbivores across five Chinese provinces, establishing the DhCN‐Virome (1,085,360 viral metagenomes). It reveals species/sample‐specific viromic signatures and cross‐species transmission dynamics, aiding unified disease control.
Yue Sun, Yong Li, Bagen Temur, Yuanqing Lin, Yuhang Liu, Le Yi, Zheng Sun, Gang Zhang, Jun Li, Yu Guo, Linchuan Li, Jinshan Cai, Wenliang Tian, Gen Meng, Lingling Jiang, Min Fang, Fuying Ding, Xuezhang Zhou, Changchun Tu, Biao He   +19 more
wiley   +1 more source

The IFMIF-DONES Irradiation Modules

Nuclear Fusion
The IFMIF-DONES Irradiation Modules consist of a set of systems designed to be tested in the IFMIF-DONES facility and which are thought to produce, in the future, an extensive, qualified and unique set of fusion-like irradiated experimental data ...
F. Arbeiter, U. Wiącek, B. Brañas, S. Gordeev, A. Kupferschmitt, Y. Qiu, A. Serikov, G. Zhou, J. Kotula, F. Arranz, F. Mota, M.I. Ortiz, D. Rapisarda, P. Araya, S. Becerril, T. Dézsi, J. Castellanos, A. Ibarra, the Eurofusion WPENS Team   +18 more
doaj   +1 more source