Results 101 to 110 of about 9,751 (308)

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Numerical simulation of MHD coupling effect relevant to COOL blanket for CFETR

Nuclear Fusion
The supercritical carbon dioxide cOoled lithium-lead (COOL) blanket is one of the candidate blankets for Chinese Fusion Engineering and Test Reactor. The lead-lithium (PbLi) is used as neutron multiplier and tritium breeder, as well as the coolant to ...
Pengdi Zhai, Kecheng Jiang, Lei Chen, Songlin Liu   +3 more
doaj   +1 more source

Features of Helium and Tritium Release from Li₂TiO₃ Ceramic Pebbles under Neutron Irradiation. [PDF]

Materials (Basel), 2023
Kulsartov T, Zaurbekova Z, Chikhray Y, Kenzhina I, Askerbekov S, Shaimerdenov A, Akhanov A, Aitkulov M, Begentayev M.   +8 more
europepmc   +1 more source

Gas core reactors for actinide transmutation and breeder applications [PDF]

This work consists of design power plant studies for four types of reactor systems: uranium plasma core breeder, uranium plasma core actinide transmuter, UF6 breeder and UF6 actinide transmuter. The plasma core systems can be coupled to MHD generators to
Clement, J. D., Rust, J. H.
core   +1 more source

Progress report no. 5 [PDF]

, 1974
Includes bibliographical referencesProgress report; June 30, 1974U.S.
Brown, Gilbert Jay, Chan, Joseph Kwok-Kwong, Choong, Philip Tsi-shien, Driscoll, Michael J., Kadiroğlu, Osman Kemal, Kalra, Manjeet Singh, Leveckis, Algis Stephen, Lukic, Yovan D., Masterson, Robert Edward, Miethe, V. A. (Virginia A.), Scheinert, Paul Albert, Shin, Jae In, Supple, A. T. Massachusetts Institute of Technology, Tagishi, Akinori, Yeung, Man-kit   +14 more
core  

The Uppsala APP Mutation Promotes Wild‐Type Amyloid‐β Aggregation and Deposition In Vivo

Advanced Science, EarlyView.
We investigated in vivo cross‐seeding of amyloid‐β (Aβ) isoforms in transgenic mice co‐expressing wild‐typeAβ and the Uppsala‐mutant Aβ variant (AβUpp), lacking six central residues. Weleveraged MALDI‐MS imaging and hyperspectral microscopy to follow spatio‐temporalAβ deposition.
Junyue Ge, María Pagnon de la Vega, Silvia Zampar, Enrica Cerilli, Srinivas Koutarapu, Ling Wu, Paul Fraser, Sertan Arkan, Vilmantas Giedraitis, Lars Lannfelt, Greta Hultqvist, Stina Syvänen, Martin Ingelsson, Jörg Hanrieder, Dag Sehlin   +14 more
wiley   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

The Nuclear Non-Proliferation Treaty\u27s Obligation to Transfer Peaceful Nuclear Energy Technology: One Proposal of a Technology [PDF]

, 1995
This Essay discusses the technology transfer provisions of the Treaty on the Non-Proliferation of Nuclear Weapons (“NPT”) and describes the Radkowsky Thorium Reactor, which is being developed as a peaceful nuclear energy ...
Grae, Seth
core   +1 more source

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

Calculation of Temperature Fields in a Lithium Ceramic Pebble Bed during Reactor Irradiation in a Vacuum. [PDF]

Materials (Basel), 2023
Chikhray Y, Kulsartov T, Zaurbekova Z, Kenzhina I, Samarkhanov K.   +4 more
europepmc   +1 more source