Results 91 to 100 of about 9,751 (308)

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Impact of MHD mixed convection on heat and mass transfer in a typical DCLL breeder blanket

Nuclear Fusion
A typical dual-coolant lead lithium liquid blanket employs eutectic liquid lithium lead alloy as coolant and tritium breeder for Tokamak nuclear fusion reactor, and is responsible for transporting heat and tritium. The blanket is subjected to both strong
Wen-Xuan Zhang, Hong-Na Zhang, Xiao-Bin Li, Feng-Chen Li   +3 more
doaj   +1 more source

Heat-Pulse Flowmeter for a Liquid Breeder Blanket

Plasma and Fusion Research, 2013
Liquid metals Li, Pb-17Li and Sn-20Li are candidate liquid breeders in fusion reactors. The development of a flowmeter that can be applied to high-temperature liquid metals is an important issue. A heat-pulse flowmeter is proposed in the present study.
Masatoshi KONDO, Kyohei SHIBANO, Teruya TANAKA, Takeo MUROGA   +3 more
openaire   +2 more sources

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

An approach to verification and validation of MHD codes for fusion applications [PDF]

, 2015
We propose a new activity on verification and validation (V&V) of MHD codes presently employed by the fusion community as a predictive capability tool for liquid metal cooling applications, such as liquid metal blankets.
Badia, Santiago, Bhattacharyayd, R., Mas de les Valls Ortiz, Elisabet, Patel, A., Smolentsev, S.   +4 more
core   +2 more sources

Integrated Single‐Cell and Spatial Transcriptomics Reveal Cell‐Type‐Specific Immune Regulatory Networks in Maize Responding to Southern Corn Rust

Advanced Science, EarlyView.
By integrating single‐nuclei and spatial transcriptomics, this study presents a stereoscopic landscape of maize leaf to Puccinia polysora infection. Epidermal and mesophyll cells initiate primary defenses via RLPs/RLKs and jasmonic acid signaling. Cell‐cell communication analyses further reveal the underlying the dynamics of the underlying immune ...
Qiongqiong Wang, Xinyan Sun, Yingchao Sun, Zeqiang Cheng, Zixiang Cheng, Shengbo Han, Ying Feng, Wenbo Yang, Huimin Li, Meichen Zhu, Xiaoling Wu, Jinghua Zhang, Jihua Tang, Honglian Li, Yanyong Cao, Canxing Duan, Yan Shi   +16 more
wiley   +1 more source

Research on Heat Transfer Performance of Different Coolants for the First Wall of the Test Blanket Module of Nuclear Fusion Reactor

南方能源建设
[Introduction] As a clean and efficient energy source, nuclear fusion promises to achieve global sustainable development in the future. For the first wall of Chinese helium-cooled solid breeder test blanket module, the temperature fields of helium, argon
Haolei ZHANG, Tao ZHOU, Chunhui XUE, Peng LIU   +3 more
doaj   +1 more source

Progress report no. 4 [PDF]

, 1973
Statement of responsibility on title-page reads: editors: M.J. Driscoll, D.D. Lanning, I. Kaplan, A.T. Supple ; contributors: A. Alvim, G.J. Brown, J.K. Chan, T.P. Choong, M.J. Driscoll, G. A. Ducat, I.A. Forbes, M.V. Gregory, S.Y. Ho, C.M. Hove, O.
Alvim, Antonio Carlos Marques, Brown, Gilbert Jay, Choong, Philip Tsi-shien, Driscoll, Michael J., Ducat, Glenn Alexander, Forbes, Ian Alexander, Gregory, Michael Vladimir, Ho, Simon Yeung-Nam, Hove, Craig Moller, Kadiroğlu, Osman Kemal, Kaplan, Irving, 1912-, Kennerley, Robert John, Lanning, David D., Lazewatsky, Joel L., Lederman, Luis, Miethe, V. A. (Virginia A.), Scheinert, Paul Albert, Supple, A. T. Massachusetts Institute of Technology, Thompson, Alan Martin, Todreas, Neil E., Tzanos, C. P., Wood, Paul Joseph   +21 more
core  

Climate Change Threatens Micronutrient Density of European Winter Wheat

Advanced Science, EarlyView.
Micronutrients are vital for human health. Wheat is a major staple crop and a significant source of minerals and B‐vitamins. The impact of climate change on their content remains largely unknown. We evaluated micronutrient levels in European winter wheat grown under historical and projected climate conditions. Our findings indicate that future climates
Da Cao, Jennifer Michel, Eline Lorer, Markus Weinmann, Jacques Le Gouis, Claire Léon, Sibille Perrochon, David Alvarez, Vincent Leemans, Iñaki Balanzategui Guijarro, Jordi Moya Laraño, Sara Sánchez Moreno, Symanczik Sarah, Waibel Matthias, Hervé Vanderschuren, Cécile Thonar, Pierre Delaplace, Dominique Van Der Straeten   +17 more
wiley   +1 more source

Progress report no. 7 [PDF]

, 1970
Statement of responsibility on title-page reads: editor: M.J. Driscoll; contributors: D.C. Aldrich, M.J. Driscoll, O.K. Kadiroglu, S. Keyvan, H.U.R. Khan, D.D. Lanning, R. Morton, J. Pasztor, T.J. Reckart, A.A. Salehi, J.I. Shin, A.T. Supple, D.J. Wargo,
Aldrich, David C., Driscoll, Michael J., Kadiroğlu, Osman Kemal, Keyvan, Shahla, Khan, Hafeez-ur-Rehman, Lanning, David D., Morton, R. (Rachel), Pásztor, János, Salehi, Ali Akbar, Shin, Jae In, Supple, A. T. Massachusetts Institute of Technology, Wargo, D. J. Massachusetts Institute of Technology, Wu, Shin-Shyong   +12 more
core