Results 131 to 140 of about 138,513 (347)

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Investigation of Wall Effect on Packing Structures and Purge Gas Flow Characteristics in Pebble Beds for Fusion Blanket by Combining Discrete Element Method and Computational Fluid Dynamics Simulation

Applied Sciences
In a tritium-breeding blanket of a fusion reaction, helium, used as a tritium-purging gas, will purge the tritium breeder pebble beds to extract the tritium in blanket. The purge gas flow characteristics will affect the tritium extraction efficiency. The
Baoping Gong, Hao Cheng, Bing Zhou, Juemin Yan, Long Wang, Long Zhang, Yongjin Feng, Xiaoyu Wang   +7 more
doaj   +1 more source

Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System

Advanced Science, EarlyView.
This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi, Weiqi Ge, Changheng Li, Bin Liu, Xiaoyi Deng, Chengjie Liu, Meijun Zheng, Pu Zhang, Lei Li, Ying Guo, Yunqi Han, Yu Yang, Yanxun V. Yu, Youngnam N. Jin   +13 more
wiley   +1 more source

Investigating the synthesis, reaction pathways, melting points and air sensitivity of Octalithium ceramics, Li8MO6, with M = Sn, Zr, Pb, and Ce

Open Ceramics
Octalithium ceramics (Li8MO6, M = Zr, Pb, Ce, Sn) are highly lithium dense compounds that have been modelled to offer significantly higher tritium breeding ratios (TBRs) compared to the current candidate breeder materials [1].
Pedr Charlesworth, Robert A. House, Peixi Cong, Robert S. Weatherup, David E.J. Armstrong, Chris Grovenor   +5 more
doaj   +1 more source

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source

ON THE CHEMISTRY OF THERMONUCLEAR REACTOR BREEDER BLANKETS

, 1958
In all likelihood, a nuclear power economy based on D-T thermonuclear reactors would require efficient breeding of tritium in blankets around such machines. Some of the chemical aspects of tritium breeder blankets are discussed by application of the principle of electroneutrality.
openaire   +2 more sources

Integrated Single‐Cell and Spatial Transcriptomics Reveal Cell‐Type‐Specific Immune Regulatory Networks in Maize Responding to Southern Corn Rust

Advanced Science, EarlyView.
By integrating single‐nuclei and spatial transcriptomics, this study presents a stereoscopic landscape of maize leaf to Puccinia polysora infection. Epidermal and mesophyll cells initiate primary defenses via RLPs/RLKs and jasmonic acid signaling. Cell‐cell communication analyses further reveal the underlying the dynamics of the underlying immune ...
Qiongqiong Wang, Xinyan Sun, Yingchao Sun, Zeqiang Cheng, Zixiang Cheng, Shengbo Han, Ying Feng, Wenbo Yang, Huimin Li, Meichen Zhu, Xiaoling Wu, Jinghua Zhang, Jihua Tang, Honglian Li, Yanyong Cao, Canxing Duan, Yan Shi   +16 more
wiley   +1 more source

High-Temperature Intrinsic Defect Chemistry of Li₈PbO₆ Ceramic Breeding Material. [PDF]

J Phys Chem C Nanomater Interfaces, 2023
Davies AW, Neilson WD, Bedford RT, Murphy ST.   +3 more
europepmc   +1 more source

ITGB1 Regulates Triple‐Negative Breast Cancer Development by Modulating the Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumorigenesis and metastasis are frequently attributed to the intricate interplay between cancer cells and the tumor microenvironment (TME). Comprehending the mechanisms and key regulators of cancer‐immune crosstalk in the TME is imperative for developing efficacious immunotherapy.
Nuozi Song, Siqi Chen, Lei Wang, Jessica Dang, Xu Cao, Stephanie Singh, Lu Yang, Jinhui Wang, Steven T. Rosen, Yingyu Wang, Chun‐Wei D. Chen, Cheng Zhang, Mingye Feng   +12 more
wiley   +1 more source

In-pile tritium release behavior and the post-irradiation experiments of Li4SiO4 fabricated by melting process

Nuclear Engineering and Technology
Understanding the tritium release and retention behavior of candidate tritium breeder materials is crucial for breeder blanket design. Recently, a melt spraying process was developed to prepare Li4SiO4 pebbles, which were subsequently subjected to the in-
Linjie Zhao, Mao Yang, Chengjian Xiao, Yu Gong, Guangming Ran, Xiaojun Chen, Jiamao Li, Lei Yue, Chao Chen, Jingwei Hou, Heyi Wang, Xinggui Long, Shuming Peng   +12 more
doaj   +1 more source