Results 31 to 40 of about 60,672 (258)

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

US solid breeder blanket design for ITER [PDF]

, 1990
The US blanket design activity has focused on the developments and the analyses of a solid breeder blanket concept for ITER. The main function of this blanket is to produce the necessary tritium required for the ITER operation and the test program ...
Majumdar, S., Ying, A., Gorbis, Z., Nelson, B., Goranson, P., Raffray, A., Baker, C. (Oak Ridge National Lab., TN (USA)), Billone, M., Attaya, H., Smith, D. (Argonne National Lab., IL (USA)), Abdou, M. (California Univ., Los Angeles, CA (USA)), Badawi, A., Blanchard, J., Kulcinski, G. (Wisconsin Univ., Madison, WI (USA)), Sviatoslavsky, I., Lin, C., Mogahed, E., Sawan, M., Gohar, Y., Williamson, D., Johnson, C.   +20 more
core  

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Processing and Waste Disposal Representative for Fusion Breeder Blanket Systems [PDF]

, 1987
This study is an evaluation of the waste handling concepts applicable to fusion breeder systems. Its goal is to determine if breeder blanket waste can be disposed of in shallow land burial, the least restrictive method under US Nuclear Regulatory ...
Finn, P.A., Vogler, S.
core  

Computer simulation of tritium release behavior of Li4SiO4 ceramic breeder with an improved packed bed model

Nuclear Analysis, 2023
In order to have a deep understanding of the tritium migration and release mechanisms in ceramic breeders, computer simulation of the tritium release behavior of Li4SiO4 ceramic breeder was performed by using an improved tritium release model.
Guangming Ran, Mao Yang, Linjie Zhao, Chengjian Xiao   +3 more
doaj   +1 more source

Myogenic Fusogen‐Engineered Lipid Nanoparticles Enhance mRNA Delivery in Skeletal Muscle

Advanced Functional Materials, EarlyView.
This study reports a biomimetic strategy of engineering full‐length Myomaker, a muscle‐specific fusogen, into lipid nanoparticles (LNPs) to harness the native myoblast fusion capability for skeletal muscle mRNA delivery. The resulting Mymk‐LNPs enhance transfection in differentiating myocytes and enable Cre‐mediated reporter activation in injured ...
Fangyu Zhang, Zhisheng Xu, Yaou Duan, Yehui Sun, Shiying Wu, Tao Long, Mateusz Durbacz, Li Zhang, Yufen Xiao, Yu‐Chung Pien, Erick D. Guerrero, Zeru Tian, Xu Wang, Pratima Basak, Sumanta Chatterjee, Ning Liu, Xiaochun Li, Eric N. Olson, Daniel J. Siegwart   +18 more
wiley   +1 more source

Engineering Concentration‐Dependent Intravitreal Mobility via Cyclic Arginine‐Enriched Nanocarrier Surface Modification: In Vivo Proof‐of‐Concept in a Porcine Large Animal Model

Advanced Healthcare Materials, EarlyView.
In this study, Hammer et al. highlight cyclic‐arginine surface engineering as a highly biocompatible, controllable, and concentration‐dependent regulator of intravitreal nanoparticle mobility in vivo in a translational large animal model. The cyclic arginine surface‐modification supports the development of next‐generation biomaterials for long‐acting ...
Maximilian Hammer, Bryan Calder Ackermann, Anna Stoß, Niklas Junker, Ludwig Geisweid, Sabrina Wohlfart, Jonathan Herth, Simon William Pohl, Manuel Ben Böhmann, André Schulz, Victor Aristide Augustin, Gerd Uwe Auffarth, Philipp Uhl   +12 more
wiley   +1 more source

Study on the flow and heat transfer characteristics of Li4SiO4 pebble bed based on DEM-CFD coupling

International Journal of Advanced Nuclear Reactor Design and Technology
The blanket is a key component for producing tritium in fusion reactors. To ensure the blanket operates effectively and safely, it is crucial to maintain efficient heat transfer in the pebble bed. Furthermore, the breeder material needs to operate within
Fangrui Guo, Qiang Lian, Shanshan Bu, Liangming Pan   +3 more
doaj   +1 more source

Long-term corrosion behavior of ODS-Eurofer in flowing Pb-15.7Li at 550°C

Nuclear Materials and Energy, 2016
Low activation ferritic-martensitic steels (RAFM-steels) are foreseen as structural materials in different blanket designs (HCLL, DCLL, WCLL) with Pb-15.7Li as breeding and partly also as cooling medium.
W. Krauss, S.-E. Wulf, J. Konys
doaj   +1 more source

Zwitterionic Polymer Coating Enabled Chronic Dopamine Sensing and Electrophysiology Recording in Free‐Moving Mice

Advanced Healthcare Materials, EarlyView.
Application of a zwitterionic poly(sulfobetaine methacrylate) (PSB) coating to microelectrode arrays and Ag/AgCl reference electrodes effectively inhibits biofouling and structural degradation. This strategy successfully enables simultaneous, long‐term electrophysiological recording and dopamine sensing in freely behaving mice, facilitating ...
Bingchen Wu, Cort Thompson, Thomas Deakin, Yan Xu, Colleen A. McClung, Xinyan Tracy Cui   +5 more
wiley   +1 more source