Results 41 to 50 of about 9,751 (308)

Electromagnetic load evaluating and optimizing approach of the blanket system during VDEs considering halo current

open access: yesNuclear Fusion, 2023
In most scenarios, the vertical displacement event (VDE) represents the most extreme electromagnetic (EM) event within the tokamak device. The significant EM loads experienced during this event have the potential to compromise the structural stability of
Mingzhun Lei   +4 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Computer simulation of tritium release behavior of Li4SiO4 ceramic breeder with an improved packed bed model

open access: yesNuclear Analysis, 2023
In order to have a deep understanding of the tritium migration and release mechanisms in ceramic breeders, computer simulation of the tritium release behavior of Li4SiO4 ceramic breeder was performed by using an improved tritium release model.
Guangming Ran   +3 more
doaj   +1 more source

Numerical study of laminar magneto-convection in a differentially heated square duct [PDF]

open access: yes, 2017
Magnetohydrodynamic pressure drops are one of the main issues for liquid metal blanket in fusion reactors. Minimize the fluid velocity at few millimeters per second is one strategy that can be employed to address the problem.
Caruso, Gianfranco   +2 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Main Nuclear Responses of the DEMO Tokamak with Different In-Vessel Component Configurations

open access: yesApplied Sciences
Research and development of the DEMOnstration power plant (DEMO) breeder blanket (BB) has been performed in recent years based on a predefined DEMO tritium breeding ratio (TBR) requirement, which determines a loss of wall surface due to non-breeding in ...
Jin Hun Park, Pavel Pereslavtsev
doaj   +1 more source

Methodology for accident analyses of fusion breeder blankets [PDF]

open access: yes2015 IEEE 26th Symposium on Fusion Engineering (SOFE), 2015
‘Fusion for Energy’ (F4E) is designing, developing, and implementing the European Helium-Cooled Lead-Lithium (HCLL) and Helium-Cooled Pebble-Bed (HCPB) Test Blanket Systems (TBSs) for ITER (Nuclear Facility INB-174). Safety demonstration is an essential element for the integration of these TBSs into ITER and accident analysis is one of its critical ...
Dobromir Panayotov   +12 more
openaire   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Long-term corrosion behavior of ODS-Eurofer in flowing Pb-15.7Li at 550°C

open access: yesNuclear Materials and Energy, 2016
Low activation ferritic-martensitic steels (RAFM-steels) are foreseen as structural materials in different blanket designs (HCLL, DCLL, WCLL) with Pb-15.7Li as breeding and partly also as cooling medium.
W. Krauss, S.-E. Wulf, J. Konys
doaj   +1 more source

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