Results 121 to 130 of about 842,561 (316)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
‘Arkhat’ - a new spring soft wheat variety for the conditions of Povolzhie and Urals
Зерновое хозяйство России, 2018 The article presents the data about a new spring soft wheat variety ‘Arkhat’ which has a realized potential of productivity (5.5 t/ha) and can produce valuable grain.
V. G. Krivobochek +2 more
doaj
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Welfare Implications of Washington Wheat Breeding Programs [PDF]
We calculate the welfare effects of the WSU wheat breeding programs for producers and consumers in Washington State, Oregon, Idaho, the United States and the rest of the world.
Nogueira, Lia, Marsh, Thomas L.
core +1 more source
The variety of spring soft wheat ‘Tulaykovskaya 108’
Зерновое хозяйство России, 2018 The article presents the technology of development of the variety of spring soft wheat ‘Tulaykovskaya 108’. In the selection process we have managed realizing the tasks appeared in the selection of parental forms.
V. V. Syukov +2 more
doaj
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Social rate of return to plant breeding research in Germany [PDF]
This article focuses on the social rate of return to plant breeding investment in Germany between 1980-2000. Starting point of the analysis is the development of total factor productivity which is decomposed into the effects of factor input and research ...
Kirschke, Dieter +4 more
core +1 more source
Maximizing Genetic Response in Breeding Schemes of Dairy Cattle with Constraints on Variance of Response [PDF]
, 1994 Predicted genetic progress in dairy cattle breeding schemes was maximized with the variances of selection responses constrained, i.e., restricted effective population sizes. This restriction would also lead to schemes with acceptable rates of inbreeding (
Woolliams, John, Meuwissen, T.H.E.
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Technology in HorticultureThe rising significance of tomato (Solanum lycopersicum L.) in human diet necessitates the continuous search for genotypes with favorable alleles for agronomic and nutritional properties from untapped genetic diversity.
Adesike Oladoyin Olayinka +2 more
doaj +1 more source