Results 131 to 140 of about 842,561 (316)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Modelling Agricultural Systems: Applications to Livestock Breeding [PDF]

Traditionally the evaluation of animal genetic traits has focused primarily on production traits and the construction of selection indices. Selection indices, however, fail to consider the effect of management practices and the environment on ...
Hattam, Caroline
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Breeding success of, & habitat use by, eider ducks [PDF]

, 1990
The study covers several facets of the ecology of the Eider ducks of the Northumberland coast between Hadston Carrs and Craster between 9 May and 1 August 1990. Special attention was given to the breeding success of the Coquet island population.
Wilson, Richard J.
core  

Genomics-Assisted Breeding: A Powerful Breeding Approach for Improving Plant Growth and Stress Resilience [PDF]

Climate change biotic and abiotic stressors lead to unpredictable crop yield losses, threatening global food and nutritional security. In the past, traditional breeding has been instrumental in fulfilling food demand; however, owing to its low efficiency,
Sajad Ali, Anshika Tyagi, Rupesh Deshmukh, Zahoor Ahmad Mir, Mohammed A. Almalki   +4 more
core   +1 more source

BREEDING OF WINTER WHEAT ON TOLERANCE TO LEAF RUST (PUCCINIA TRITICINA ERIKS.) IN MOSCOW RIA “NEMCHINOVKA”

Зерновое хозяйство России, 2018
The genes of P.triticina tolerance of the varieties of soft winter wheat have been studied by test-isolators. The experiment was based on Flor’s theory ‘gene for gene’, when a tolerant gene matches virulence.
B. I. Sandukhadze, M. I. Rybakova, G. V. Kochetygov, A. A. Morozov, E. K. Sandukhadze, V. V. Bugrova   +5 more
doaj  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Behavioural Endocrinology of Breeding Adelie Penguins (Pygoscelis adeliae) [PDF]

, 2008
Measuring hormonal changes is vital for understanding how the social and physical environment influences behaviour, reproduction and survival. Various methods of hormone measurement exist, potentially explaining variation in results across studies ...
Ninnes, Calum Edward
core  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source