Results 91 to 100 of about 506,342 (292)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Neutronic investigation of waste transmutation option without partitioning and transmutation in a fusion-fission hybrid system

Nuclear Engineering and Technology, 2018
A feasibility of reusing option of spent nuclear fuel in a fusion-fission hybrid system without partitioning was checked as an alternative option of pyro-processing with critical reactor system. Neutronic study was performed with MCNP 6.1 for this option,
Seong Hee Hong, Myung Hyun Kim
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Neutronics analysis of spin-polarized fuel in spherical tokamaks

Nuclear Fusion
The effect of spin-polarized deuterium–tritium fuel on the blanket, magnets, and surrounding structures is analyzed for a spherical tokamak fusion power plant.
Jin Whan Bae, Katarzyna Borowiec, Vittorio Badalassi, Jason Parisi, Ahmed Diallo, Jon Menard, Andrei Khodak, Thomas Brown   +7 more
doaj   +1 more source

Conceptual design study of the tritium breeding unit for verifying the long-term performance of the breeding blanket

Nuclear Engineering and Technology
Fusion reactors produce high-energy neutrons through the Deuterium-Tritium (DT) reaction. The long-term performance verification and structural integrity assessment of the breeding blanket under continuous plasma operation are essential for the ...
Hyoseong Gwon, Dohyun Kim, Mu-Young Ahn, Seonghee Hong   +3 more
doaj   +1 more source

DEMO Breeding Blanket Concepts in EUROfusion work package breeding blanket (WPBB)

, 2021
Zhou, Guangming, Hernández, Francisco A .   +1 more
openaire   +3 more sources

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Development status of 30 MeV cyclotron-based neutron source in Korea [PDF]

EPJ Web of Conferences
KAERI has developed plasma heating systems and fusion engineering technologies such as blanket first wall and breeding blanket for nuclear fusion reactor development, as well as nuclear data production.
Lee Dong Won, Lee Kihyun, Jung Bongki, Lee Jongchul, Park Jeong Hoon, Kim Jongyul, Moon Myung Kook, Lee Chang Hee   +7 more
doaj   +1 more source

Neutronic analysis of a dual He/LiPb coolant breeding blanket for DEMO [PDF]

, 2010
A conceptual design of a DEMO fusion reactor is being developed under the Spanish Breeding Blanket Technology Programme: TECNO_FUS based on a He/LiPb dual coolant blanket as reference design option.
J. Sanz, L. Sedano, Sedano, L., Ogando Serrano, Francisco, Gómez Ros, J.M., J.M. Gómez-Ros, G. Veredas, Veredas, G., F. Ogando, I. Palermo, Sanz Gonzalo, Javier, Catalán, J.P., Palermo, I., J.P. Catalán   +13 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source