Results 111 to 120 of about 4,264 (289)
FEBS Open Bio, EarlyView.KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura +19 more
wiley +1 more source
FEBS Open Bio, EarlyView.In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin +12 more
wiley +1 more source
Minimum-thickness blanket/shield with optimum tritium breeding and shielding effectiveness [PDF]
, 1978 A blanket/shield assembly for a fusion reactor has been designed through extensive optimization studies. The design was optimized under the following constraints: (a) minimum overall thickness, (b) tritium breeding ratio of 1.10, (c) thermal energy ...
Gerstl, S.A.W.
core
Design of the helium cooled lithium lead breeding blanket in CEA: from TBM to DEMO
, 2017 International audienceThe helium cooled lithium lead (HCLL) blanket concept was originally developed in CEA at the beginning of 2000: it is one of the two European blanket concepts to be tested in ITER in the form of a test blanket module (TBM) and one ...
J.-C. Jaboulay +12 more
core +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Tritium-breeding self-sufficiency of DEMO reactors with a water-cooled Pb17Li blanket
, 1993 In the frame of the studies developed for DEMO breeding blankets, a type of blanket with Pb17Li as breeder and water as coolant has been developed at the JRC-Ispra.
Zucchetti, Massimo +7 more
core +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
Nuclear Analysis of the HCLL "Advanced-Plus" Breeding Blanket with Single Module Segment Structure
, 2019 International audienceThis paper presents the nuclear analysis carried out with the TRIPOLI-4$^R$ Monte-Carlo code for the Helium Cooled Lithium Lead (HCLL) Advanced-Plus breeding blanket design using the Single Module Segment (SMS) option in the ...
Boullon, Rémi +3 more
core
, 2016 The determination of an optimal configuration for the breeder zone (BZ) cooling tubes is one of the most important issues in the DEMO Water-Cooled Lithium Lead (WCLL) breeding blanket R&D activities, since BZ cooling tubes spatial distribution should ...
CHIOVARO, Pierluigi +5 more
core +1 more source
Main Nuclear Responses of the DEMO Tokamak with Different In-Vessel Component Configurations
Applied SciencesResearch and development of the DEMOnstration power plant (DEMO) breeder blanket (BB) has been performed in recent years based on a predefined DEMO tritium breeding ratio (TBR) requirement, which determines a loss of wall surface due to non-breeding in ...
Jin Hun Park, Pavel Pereslavtsev
doaj +1 more source