Results 101 to 110 of about 38,108 (302)

Neutronics analysis of spin-polarized fuel in spherical tokamaks

Nuclear Fusion
The effect of spin-polarized deuterium–tritium fuel on the blanket, magnets, and surrounding structures is analyzed for a spherical tokamak fusion power plant.
Jin Whan Bae, Katarzyna Borowiec, Vittorio Badalassi, Jason Parisi, Ahmed Diallo, Jon Menard, Andrei Khodak, Thomas Brown   +7 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Conceptual design study of the tritium breeding unit for verifying the long-term performance of the breeding blanket

Nuclear Engineering and Technology
Fusion reactors produce high-energy neutrons through the Deuterium-Tritium (DT) reaction. The long-term performance verification and structural integrity assessment of the breeding blanket under continuous plasma operation are essential for the ...
Hyoseong Gwon, Dohyun Kim, Mu-Young Ahn, Seonghee Hong   +3 more
doaj   +1 more source

DEMO Breeding Blanket Concepts in EUROfusion work package breeding blanket (WPBB)

, 2021
Zhou, Guangming, Hernández, Francisco A .   +1 more
openaire   +3 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Gas core reactors for actinide transmutation and breeder applications [PDF]

This work consists of design power plant studies for four types of reactor systems: uranium plasma core breeder, uranium plasma core actinide transmuter, UF6 breeder and UF6 actinide transmuter. The plasma core systems can be coupled to MHD generators to
Clement, J. D., Rust, J. H.
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Development of water-cooled cylindrical blanket in JA DEMO

Nuclear Fusion
The concept of the tritium breeding blanket for Japan’s DEMOnstration fusion reactor (JA DEMO) has been developed with pressure tightness against in-box loss-of-coolant accidents based on a water-cooled solid breeder concept.
Someya Youji, Tanigawa Hiroyasu, Sakamoto Yoshiteru, the Joint Special Design Team for Fusion DEMO   +3 more
doaj   +1 more source

High-dose neutron irradiation of beryllium and titanium beryllide: Summary and outlook

Nuclear Materials and Energy
The irradiation experiment conducted in the HFR material testing reactor, under conditions simulating the operating environment of the DEMO breeding blanket, along with subsequent post-irradiation examinations (PIEs) of irradiated beryllium-based ...
Vladimir Chakin, Rolf Rolli, Hans-Christian Schneider, Ramil Gaisin, Pavel Vladimirov, Michael Klimenkov, Michael Duerrschnabel, Nikolai Zimber, Michael Rieth, Bronislava Gorr, Francisco A. Hernández, Dirk Radloff, Alexander Fedorov, Milan Zmitko, Masaru Nakamichi, Sergey Udartsev   +15 more
doaj   +1 more source