Results 71 to 80 of about 38,108 (302)

Numerical study of laminar magneto-convection in a differentially heated square duct [PDF]

, 2017
Magnetohydrodynamic pressure drops are one of the main issues for liquid metal blanket in fusion reactors. Minimize the fluid velocity at few millimeters per second is one strategy that can be employed to address the problem.
Caruso, Gianfranco, Giannetti, Fabio, Tassone, Alessandro   +2 more
core   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Breeding blanket mock-up testing in IFMIF-DONES

Nuclear Fusion
The fusion community is looking for solutions to qualify the breeding blankets (BB) before their final testing in DEMO. Thus, ambitious and attractive proposals, like the Volumetric Neutron Source, are being explored.
D. Rapisarda, P. Arena, F. Arranz, B. Brañas, F. Mota, M.I. Ortiz, A. Serikov, G. Zhou   +7 more
doaj   +1 more source

Calculating the 3D magnetic field of ITER for European TBM studies

, 2015
The magnetic perturbation due to the ferromagnetic test blanket modules (TBMs) may deteriorate fast ion confinement in ITER. This effect must be quantified by numerical studies in 3D.
Asunta, O, Bergmans, T, Gagliardi, M, Galabert, J, Hirvijoki, Eero, Kurki-Suonio, Taina, Sipilä, S, Snicker, A, Särkimäki, K, Äkäslompolo, S   +9 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A Preliminary Exergy Analysis of the EU DEMO Fusion Reactor [PDF]

, 2019
Purpose of the present study is the exergy analysis of EU DEMO pulsed fusion power plant considering the Primary Heat Transfer Systems, the Intermediate Heat Transfer System (IHTS) including the Energy Storage System (ESS) as a first option to ensure the
Caruso, Gianfranco, Giannetti, Fabio, Palazzo, Pierfrancesco   +2 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Three-dimensional MHD flow and heat transfer in a channel with internal obstacle [PDF]

, 2018
The magnetohydrodynamic flow and heat transfer of a liquid metal in a channel past a circular cylinder with walls of non-uniform conductivity were investigated. The applied magnetic field was transversal to the forced flow (x-direction) and coplanar with
Caruso, Gianfranco, Gramiccia, Luciano, Tassone, Alessandro   +2 more
core   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source