Results 111 to 120 of about 22,173 (305)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Experimental demonstration of advanced ISO-FLUX equilibrium control during the first JT-60SA operational phase under DEMO-relevant conditions

Nuclear Fusion
In the control of large superconducting tokamaks, particularly for devices like DEMO reactors, where no stabilizing plates or in-vessel coils can be mounted due to the existence of tritium breeding blankets, position, shape, and current of plasmas must ...
S. Inoue, Y. Miyata, S. Kojima, M. Takechi, R. Sano, T. Wakatsuki, H. Urano, M. Yoshida, T. Suzuki, the JT-60SA Integrated Project Team   +9 more
doaj   +1 more source

Análisis de la transmutación de Actínidos Minoritarios en un reactor rápido de sodio con modelo de carga homogéneo mediante el código MCNPX-CINDER [PDF]

, 2010
El reactor rápido refrigerado por sodio (SFR) constituye uno de los conceptos más prometedores de los seis considerados en la Generación IV de reactores nucleares, encontrándose actualmente en fase de investigación.
Aragonés Beltrán, José María, García Herranz, Nuria, Ochoa Valero, Raquel   +2 more
core  

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

A Solid breeder tokamak blanket designed for failure mode operation [PDF]

, 1977
Statement of responsibility on title-page reads: Franklin Chen, Peter Griffith, Thomas McManamy, and Gary Was"May 1977.""This study is basically an integration and extension of a doctor's thesis by Franklin Chen and a master's thesis by Gary Was ...
Chen, Franklin Fun Kun, Griffith, P. (Peter), McManamy, Thomas Joseph, Was, Gary S. (Gary Steven), 1953-   +3 more
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Experimental Investigation on Pressure Drops of Purge Gas Helium in Packed Pebble Beds for Nuclear Fusion Blanket

Energies
The flow characteristics of purge gas helium in the pebble bed of the tritium breeding blanket are important in analyzing the tritium purging process and optimizing the design of the solid breeder blanket.
Hao Cheng, Baoping Gong, Bing Zhou, Juemin Yan, Long Wang, Long Zhang, Yongjin Feng, Xiaoyu Wang   +7 more
doaj   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source

Nuclear Development Strategies with Limited Natural Uranium Requirements [PDF]

, 1979
In view of the fact that the world's high-grade natural uranium resources are limited, alternative ways of using these resources more efficiently are of interest in the line of research undertaken by IIASA's Energy Systems Program.
Nakicenovic, N., Perry, A.M.
core  

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source