Results 101 to 110 of about 22,248 (302)

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Accident-tolerant hybrid ceramics for fusion breeding blanket

Materials & Design
In a water-cooled ceramic breeding blanket for fusion reactors, hydrogen gas generation by steam oxidation of metallic Be compounds (i.e. neutron multiplier) in a loss-of-coolant accident (LOCA) raises major safety concerns. Li–Be hybrid ceramics has a potential to reduce hydrogen generation significantly, however, the stable compositions and ...
Keisuke Mukai, Taehyun Hwang, Minoru Kusaba, Jae-Hwan Kim   +3 more
openaire   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

DEMO Breeding Blanket Concepts in EUROfusion work package breeding blanket (WPBB)

, 2021
Zhou, Guangming, Hernández, Francisco A .   +1 more
openaire   +3 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Analysis of a segmentation approach to breeder blanket design and the utilisation of FLiBe as a novel neutron reflector

Nuclear Fusion
Tritium production in a fusion reactor is essential for a deuterium-tritium burning plasma source, and designing a lithium-containing breeder blanket is crucial for a closed fuel cycle in an electricity-to-grid power plant.
Adam J. Barker, Mark R. Gilbert, Philip D. Edmondson   +2 more
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Accelerating the engineering design of breeder blankets with parametric optimisation and sequential learning

Frontiers in Nuclear Engineering
The competing requirements of fusion breeder blankets and the high dimensionality of their design space necessitate a systematic treatment to map the variations in performance against given objective metrics and to understand the operational envelope. In
Luke Humphrey, Helen Brooks, Siddharth Mungale, Andrew Davis, David Foster   +4 more
doaj   +1 more source

Coyote\u27s Tale on the Old Oregon Trail: Challenging Cultural Memory through Narrative at the Tamástslikt Cultural Institute [PDF]

, 2005
This essay examines the oppositional narratives presented in a Native American museum in order to explore the efficacy of narrative as both a strategy for resistance to hegemonic narratives of the settling of the West and a medium for sharing culture ...
Miller, Jackson B.
core   +1 more source