Results 111 to 120 of about 22,248 (302)

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Exhaust assessment of a European Volumetric Neutron Source (EU-VNS) using SOLPS-ITER

Nuclear Materials and Energy
EUROfusion considers a volumetric neutron source (EU-VNS) to generate a neutron wall load of about 0.5MW/m2 to qualify tritium breeding blankets early in support of EU-DEMO that mitigates the risk of a late testing for required nuclear technology.
S. Wiesen, Ch. Bachmann, M. Siccinio, J. Boscary, C. Bourdelle, M. Coleman, G. Federici, F. Maviglia, R. Neu   +8 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Fatigue lifetime prediction and reliability assessment for fusion blankets under pulsed operational loading

Nuclear Fusion
The breeding blanket is a critical component of magnetic confinement fusion reactors. The reliability, availability, maintainability, and inspectability (RAMI) of the blanket has been recognized as a major challenge on the pathway to commercial fusion ...
Qingzhu Liang, Xuebin Ma, Xiaoman Cheng, Lei Chen, Songlin Liu   +4 more
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Experimental demonstration of advanced ISO-FLUX equilibrium control during the first JT-60SA operational phase under DEMO-relevant conditions

Nuclear Fusion
In the control of large superconducting tokamaks, particularly for devices like DEMO reactors, where no stabilizing plates or in-vessel coils can be mounted due to the existence of tritium breeding blankets, position, shape, and current of plasmas must ...
S. Inoue, Y. Miyata, S. Kojima, M. Takechi, R. Sano, T. Wakatsuki, H. Urano, M. Yoshida, T. Suzuki, the JT-60SA Integrated Project Team   +9 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A Solid breeder tokamak blanket designed for failure mode operation [PDF]

, 1977
Statement of responsibility on title-page reads: Franklin Chen, Peter Griffith, Thomas McManamy, and Gary Was"May 1977.""This study is basically an integration and extension of a doctor's thesis by Franklin Chen and a master's thesis by Gary Was ...
Chen, Franklin Fun Kun, Griffith, P. (Peter), McManamy, Thomas Joseph, Was, Gary S. (Gary Steven), 1953-   +3 more
core  

Extended Inclusive Fitness Theory bridges Economics and Biology through a common understanding of Social Synergy

, 2015
Inclusive Fitness Theory (IFT) was proposed half a century ago by W.D. Hamilton to explain the emergence and maintenance of cooperation between individuals that allows the existence of society. Contemporary evolutionary ecology identified several factors
Jaffe, Klaus
core   +1 more source