Results 81 to 90 of about 22,248 (302)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Searching for exotic scalars at fusion reactors

Journal of High Energy Physics
Part of the energy created in deuterium-tritium fusion reactors is carried away from plasma by a high-intensity neutron flux, which is then absorbed by the reactor’s inner walls.
Chaja Baruch, Patrick J. Fitzpatrick, Tony Menzo, Yotam Soreq, Sokratis Trifinopoulos, Jure Zupan   +5 more
doaj   +1 more source

Tritium Extraction from Liquid Blankets of Fusion Reactors via Membrane Gas–Liquid Contactors

Journal of Nuclear Engineering
The exploitation of fusion energy in tokamak reactors relies on efficient and reliable tritium management. The tritium needed to sustain the deuterium–tritium fusion reaction is produced in the Li-based blanket surrounding the plasma chamber, and ...
Silvano Tosti, Luca Farina
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Timing as a sexually selected trait: the right mate at the right moment [PDF]

, 2017
Sexual selection favours the expression of traits in one sex that attract members of the opposite sex for mating. The nature of sexually selected traits such as vocalization, colour and ornamentation, their fitness benefits as well as their costs have ...
Buck, C. Loren, Casagrande, Stefania, Dominoni, Davide, Greives, Timothy, Hau, Michaela, Hazlerigg, David, Hut, Roelof A., Wagner, Gabriela   +7 more
core   +3 more sources

Progress in EU Breeding Blanket design and integration

Fusion Engineering and Design, 2018
In Europe (EU), in the frame of the EUROfusion consortium activities, four Breeding Blanket (BB) concepts are being developed with the aim of fulfilling the performances required by a near-term fusion power demonstration plant (DEMO) in terms of tritium self-sufficiency and electricity production.
Cismondi, F., Boccaccini, L. V., Aiello, G., Aubert, J., Bachmann, C., Barrett, T., Barucca, L., Bubelis, E., Ciattaglia, S., Del Nevo, A., Diegele, E., Gasparotto, M., Di Gironimo, G., Di Maio, P. A., Hernandez, F., Federici, G., Fernández-Berceruelo, I., Franke, T., Froio, A., Gliss, C., Keep, J., Loving, A., Martelli, E., Maviglia, F., Moscato, I., Mozzillo, R., Poitevin, Y., Rapisarda, D., Savoldi, L., Tarallo, A., Utili, M., Vala, L., Veres, G., Zanino, R.   +33 more
openaire   +6 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

On the Feasibility of Self-Sustainable Deuterium Production in Fusion Reactors Using an Ionization Chamber [PDF]

, 2015
In this technical note we examine a method for self-sustainable (in-situ) deuterium production in a fusion reactor, using a very different approach to those considered in previous studies. Here, instead of pursuing the production of deuterium via neutron
Arias, FJ, Parks, GT
core   +2 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

The effects of extended photoperiod and warmth on hair growth in ponies and horses at different times of year.

PLoS ONE, 2020
Photoperiod is considered the most dominant environmental cue allowing animals to anticipate and adapt to seasonal changes. In seasonally breeding mammals, changes in daylength alter pineal melatonin secretion and pituitary prolactin secretion.
Christiane O'Brien, Megan Ruth Darcy-Dunne, Barbara Anne Murphy   +2 more
doaj   +1 more source