Results 71 to 80 of about 22,248 (302)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Uncertainty assessment methodologies applied to Tritium production in fusion lithium breeding blankets [PDF]

, 2011
- Need of Tritium production - Neutronic objectives - The Frascati experiment - Measurements of Tritium ...
Cabellos de Francisco, Oscar Luis, Diez de la Obra, Carlos Javier, Martínez, J.S.   +2 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Three-dimensional model of DEMO-FNS facility considering neutronics and radiation shield problems

Heliyon, 2019
Recent neutronics studies of blankets for tokamak-based demonstration fusion neutron source (DEMO-FNS) showed a crucial influence of coolant composition on the transmutation rate of transuranic elements and tritium breeding in the system.
A.V. Zhirkin, B.V. Kuteev
doaj   +1 more source

Progress report no. 2 [PDF]

, 1971
Statement of responsibility on title-page reads: Editors: I.A. Forbes, M.J. Driscoll, N.C. Rasmussen, D.D. Lanning and I. Kaplan; Contributors: S.T. Brewer, G.J. Brown, P.DeLaquil, III, M.J. Driscoll, I.A. Forbes, C.W. Forsberg, E.P.
Brewer, Shelby Templeton, Brown, Gilbert Jay, De Laquil, Pascal, Driscoll, Michael J., Forbes, Ian Alexander, Forsberg, Charles Winfield, Gyftopoulos, E. P., Hendrick, Peter Ladd, Kang, Chʻang-sun, Kaplan, Irving, 1912-, Klucar, James Leonard, Lanning, David D., Leung, Timothy Chung-tim, Mason, Edward A. (Edward Archibald), 1924-, Ortiz, Nestor Ruben, Passman, Neil Alan, Rasmussen, Norman C., Rickard, I. C. Massachusetts Institute of Technology, Rogers, V. C. (Vern Child), 1941-, Sullivan, G. E. Massachusetts Institute of Technology, Supple, A. T. Massachusetts Institute of Technology, Tzanos, C. P., Westlake, William James   +22 more
core  

Design, construction and evaluation of a facility for the simulation of fast reactor blankets [PDF]

, 1970
"February 1970."Statement of responsibility on title-page reads: I.A. Forbes, M.J. Driscoll, T.J. Thompson, I.Kaplan and D.D. LanningAlso issued as a Ph. D. thesis in the Dept.
Driscoll, Michael J., Forbes, Ian Alexander, Kaplan, Irving, 1912-, Manning, David D., Thompson, Theos Jardin, 1918-1970   +4 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Neutronics experiment of tritium breeding in supercritical CO2 cooled lithium-lead blanket mock-up by D–T neutron irradiation

Nuclear Fusion
The tritium breeding capacity of fusion blankets is a critical factor in achieving tritium self-sufficiency in fusion reactors. Current designs for tritium production in blankets are based on neutronics simulations, whose accuracy requires experimental ...
Qiankun Shao, Qingjun Zhu, Zuocong Liu, Tianyi Liu, Jie Bao, Songlin Liu   +5 more
doaj   +1 more source

Conceptual radiation shielding design of the integrated breeding test facility at KFE

Nuclear Engineering and Technology
The Integrated Breeding Test Facility (IBTF) is being developed by Korea Institute of Fusion Energy to assess the long-term performance of breeding blankets under continuous irradiation environment.
Hyoseong Gwon, Dohyun Kim, Seonghee Hong, Mu-Young Ahn   +3 more
doaj   +1 more source