Results 61 to 70 of about 1,329 (294)

The effect of reactor size on the breeding economics of LMFBR blankets [PDF]

open access: yes, 1975
"February, 1975."Also issued as an Sc. D. thesis written by the first author and supervised by the second author, MIT Dept. of Nuclear Engineering, 1975Includes bibliographical references (pages 344-346)The effect of reactor size on the neutronic and ...
Tagishi, Akinori, Driscoll, Michael J.
core  

Design analyses of self-cooled liquid metal blankets

open access: yes, 1986
A trade-off study of liquid metal self-cooled blankets was carried out to define the performance of these blankets and to determine the potential to operate at the maximum possible values of the performance parameters.
Gohar, Y.
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Neutronics experiment of tritium breeding in supercritical CO2 cooled lithium-lead blanket mock-up by D–T neutron irradiation

open access: yesNuclear Fusion
The tritium breeding capacity of fusion blankets is a critical factor in achieving tritium self-sufficiency in fusion reactors. Current designs for tritium production in blankets are based on neutronics simulations, whose accuracy requires experimental ...
Qiankun Shao   +5 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Conceptual radiation shielding design of the integrated breeding test facility at KFE

open access: yesNuclear Engineering and Technology
The Integrated Breeding Test Facility (IBTF) is being developed by Korea Institute of Fusion Energy to assess the long-term performance of breeding blankets under continuous irradiation environment.
Hyoseong Gwon   +3 more
doaj   +1 more source

Three-dimensional model of DEMO-FNS facility considering neutronics and radiation shield problems

open access: yesHeliyon, 2019
Recent neutronics studies of blankets for tokamak-based demonstration fusion neutron source (DEMO-FNS) showed a crucial influence of coolant composition on the transmutation rate of transuranic elements and tritium breeding in the system.
A.V. Zhirkin, B.V. Kuteev
doaj   +1 more source

Helium-3 blankets for tritium breeding in fusion reactors

open access: yes, 1988
It is concluded that He-3 blankets offers considerable promise for tritium breeding in fusion reactors: good breeding potential, low operational risk, and attractive safety features.
Vesey, Roger   +4 more
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

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