Results 91 to 100 of about 407,600 (313)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Time versus energy minimization migration strategy varies with body size and season in long-distance migratory shorebirds

Movement Ecology, 2017
Background Migrants have been hypothesised to use different migration strategies between seasons: a time-minimization strategy during their pre-breeding migration towards the breeding grounds and an energy-minimization strategy during their post-breeding
Meijuan Zhao, Maureen Christie, Jonathan Coleman, Chris Hassell, Ken Gosbell, Simeon Lisovski, Clive Minton, Marcel Klaassen   +7 more
doaj   +1 more source

Optimization of the composition of crop collections for ex situ conservation [PDF]

, 2009
Many crop genetic resources collections have been established without a clearly defined conservation goal or mandate, which has resulted in collections of considerable size, unbalanced composition and high levels of duplication.
Engels, J.M.M., Hintum, T.J.L., van, Hoekstra, R., Treuren, R., van   +3 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Stochastic simulation to optimize rice breeding at IRRI

Frontiers in Plant Science
IntroductionGenetic improvement in rice increased yield potential and improved varieties for farmers over the last decades. However, the demand for rice is growing while its cultivation faces challenges posed by climate change.
Fallou Seck, Fallou Seck, Parthiban Thathapalli Prakash, Giovanny Covarrubias-Pazaran, Tala Gueye, Ibrahima Diédhiou, Sankalp Bhosale, Suresh Kadaru, Jérôme Bartholomé, Jérôme Bartholomé, Jérôme Bartholomé   +10 more
doaj   +1 more source

Improved quality and disease management in diverse populations [PDF]

, 2013
Improved biodiversity is one of the key principles in organic farming and therefore organic plant breeding seeks alternatives to the currently dominant pureline monocultures.
Borgen, Anders
core  

Survival rates of captive-bred Asian Houbara Chlamydotis macqueenii in a hunted migratory population [PDF]

, 2016
Asian Houbara Chlamydotis macqueenii numbers are declining owing to unsustainable levels of hunting and poaching, with the main conservation response being population reinforcement through the release of captive-bred birds.
Burnside, Robert, Collar, Nigel, Dolman, Paul, Scotland, Keith   +3 more
core   +1 more source

Multi-objective optimized breeding strategies [PDF]

, 2017
Multi-objective optimization is an emerging field in mathematical optimization which involves optimization a set of objective functions simultaneously. The purpose of most plant and animal breeding programs is to make decisions that will lead to sustainable genetic gains in more than one traits while controlling the amount of co-ancestry in the ...
Akdemir, Deniz, Isidro Sánchez, Julio
openaire   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Biopower and an ecology of genes : seeing livestock as meat via genetics [PDF]

, 2015
This book chapter focuses on some of the implications of what has been represented as a radical change in livestock breeding for thinking about meat in relation to living farm animals: the use of genetic techniques in selecting breeding animals.
Holloway, Lewis
core   +1 more source