Genomics-assisted breeding – A revolutionary strategy for crop improvement
Journal of Integrative Agriculture, 2017 Food shortages arise more frequently owing to unpredictable crop yield losses caused by biotic and abiotic stresses. With advances in molecular biology and marker technology, a new era of molecular breeding has emerged that has greatly accelerated the ...
Peng-fei LENG +2 more
doaj +1 more source
A comprehensive overview of breeding strategy to improve phenotypic and quality traits in Valeriana jatamansi Jones. [PDF]
Heliyon, 2023 Gautam RD +5 more
europepmc +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Genomic selection with rapid cycling: Current insights and future prospects
Crop Breeding and Applied Biotechnology, 2021 Enhancing the rate of genetic gain in plant breeding program is critical to address global food security in the face of climate change and a growing population.
Francisco Gomez +2 more
doaj
Regulatory network of rice in response to heat stress and its potential application in breeding strategy. [PDF]
Mol Breed, 2023 Ma Z +6 more
europepmc +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Redefining crop breeding strategy for effective use of nitrogen in cropping systems. [PDF]
Commun Biol, 2022 Ciampitti IA +3 more
europepmc +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
A fast breeding strategy creates fragrance- and anthocyanin-enriched rice lines by marker-free gene-editing and hybridization. [PDF]
Mol Breed, 2023 Shi T +10 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source