Results 101 to 110 of about 407,600 (313)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Review: Towards the agroecological management of ruminants, pigs and poultry through the development of sustainable breeding programmes. II. Breeding strategies [PDF]

, 2016
Agroecology uses ecological processes and local resources rather than chemical inputs to develop productive and resilient livestock and crop production systems.
Belloc, Catherine, Bidanel, J., Brochard, M., Delaby, Luc, Dourmad, J. Y., Dumont, B., Ezanno, Pauline, Fortun-Lamothe, L., Foucras, G., Frappat, Brigitte, Gonzalez-Garcia, E., Hazard, D., Larzul, C., Lubac, S., Mignon-Grasteau, S., Moreno, C. R., Phocas, F., Tixier-Boichard, M.   +17 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Current status for utilization of cold resistance genes and strategies in wheat breeding program

Frontiers in Genetics
Low temperature chilling is one of the major abiotic stresses affecting growth and yield of Triticum aestivum L. With global climate change, the risk of cold damage in wheat production has increased.
Shijie Ma, Xiaorong Huang, Xiaoqing Zhao, Lilong Liu, Li Zhang, Binjie Gan   +5 more
doaj   +1 more source

AgrEvo: From crop protection to crop production [PDF]

, 2001
AgrEvo is a German producer of crop protection products. In 1995 it made the strategic decision to shift from crop protection to crop production, with the help of biotechnology.
Bijman, J.
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Conservation and use of genetic resources of underutilized crops in the Americas - A continental analysis [PDF]

, 2014
Latin America is home to dramatically diverse agroecological regions which harbor a high concentration of underutilized plant species, whose genetic resources hold the potential to address challenges such as sustainable agricultural development, food ...
Galluzzi, Gea, López Noriega, Isabel
core   +3 more sources

Animal exploitation and breeding strategies

, 2020
Zooarchaeological studies in Central Asia are still very scarce. The analysis of the faunal assemblage retrieved during seven archaeological campaigns at the fortified settlement of Kojtepa allows obtaining information about the breeding strategy and animals exploitation in the Samarkand oasis during late and post-Hellenistic period, ca.
Maini Elena, Serrone Eleonora
openaire   +2 more sources

Harnessing monocrop breeding strategies for intercrops

Frontiers in Plant Science
Intercropping is considered advantageous for many reasons, including increased yield stability, nutritional value and the provision of various regulating ecosystem services. However, intercropping also introduces diverse competition effects between the mixing partners, which can negatively impact their agronomic performance.
Dubey, Reena, Zustovi, Riccardo, Landschoot, Sofie, Dewitte, Kevin, Verlinden, Greet, Haesaert, Geert, Maenhout, Steven   +6 more
openaire   +4 more sources