Results 81 to 90 of about 2,771 (230)

The Chemistry and Biology of the Tetrodotoxin Natural Product Family

Angewandte Chemie International Edition, Volume 64, Issue 35, August 25, 2025.
Tetrodotoxin is best known as the poison of the pufferfish, which is a delicacy in Japanese cuisine. Its toxicity arises from the selective blockage of NaV channels, which is depicted for the NaV1.7 pore, highlighting the DEKA motif, which permeates sodium ions.
Benedikt Nißl, Marcel Mülbaier, Francesca Grisoni, Dirk Trauner, Marcel Bermúdez, Clemens Dialer, David B. Konrad   +6 more
wiley   +1 more source

A catastrophic marine mortality event caused by a complex algal bloom including the novel brevetoxin producer, Karenia cristata (Dinophyceae)

bioRxiv
Harmful algal blooms of Karenia brevis (Dinophyceae) are a global anomaly, occurring in one location worldwide, causing severe marine and acute human impacts via brevetoxins (BTX).
Shauna A. Murray, Christopher J S Bolch, S. Brett, Cheong Xin Chan, M. Doubell, Hazel Farrell, Greta Gaiani, Hannah Greenhough, G. Hallegraeff, Tamsyne Smith Harding, D. Harwood, Robert G. Hatfield, Neil Macdonald, I. Moody, Hugo Bastos de Oliveira, Lesley Rhodes, A. Selwood, Justin R. Seymour, N. Siboni, A. Snigirova, Nikola Streiber, C. Styan, A. Rolton, Clinton Wilkinson, Kirsty Smith   +24 more
semanticscholar   +1 more source

Semisynthesis of S-Desoxybrevetoxin-B2 and Brevetoxin-B2, and Assessment of Their Acute Toxicities

, 2016
Brevetoxins are neurotoxins associated with blooms of marine algae such as Karenia brevis and can accumulate in the marine food chain, causing intoxication of marine animals and people consuming seafood.
John S. Ramsdell (60818), Roel van Ginkel (2296699), Alistair L. Wilkins (1288317), Andrew I. Selwood (2296702), Christopher O. Miles (1288326), Dwayne J. Jensen (1577149), Rex Munday (2296696), Janine M. Cooney (1577143)   +7 more
core   +2 more sources

Opinion of the French Agency for Food, Environmental and Occupational Health & Safety (ANSES) on the risks to human health associated with the proliferation of Ostreopsis spp. on the Basque coast

Food Risk Assess Europe, Volume 3, Issue 2, April 2025.
Abstract In France, the presence of marine microalgae of the genus Ostreopsis has been identified repeatedly on the Mediterranean coast for several years, whereas on the French Basque coasts its presence is much more recent. In the summers of 2021 and 2022, major Ostreopsis flowering episodes were reported on the Basque coast, resulting in several ...
Rodolphe Lemée, Jean‐François Humbert, Eric Abadie, Zouher Amzil, Elisa Berdalet, Ronel Biré, Marie‐Yasmine Dechraoui Bottein, Luc de Haro, Nicolas Delcourt, Valérie Fessard, Jean‐Philippe Jaeg, César Mattei, Anne Oppliger, Anne‐Sophie Pavaux, Eva Ternon, Gilles Bornert, Anne Togola, Jean Baron, Jean‐Luc Boudenne, Nicolas Cimetiere, Bruno Coulomb, Christophe Dagot, Sabine Denooz, Isabelle Dublineau, Frédéric Feder, Matthieu Fournier, Stéphane Garnaud‐Corbel, Nathalie Garrec, Johnny Gasperi, Julio Gonçalvès, Jean‐Louis Gonzalez, Olivier Horner, Michel Joyeux, Jérôme Labanowski, Sophie Lardy‐Fontan, Françoise Lucas, Christophe Mechouk, Laurent Moulin, Damien Mouly, Fabienne Petit, Catherine Quiblier, Pauline Rousseau‐Gueutin, Marie‐Pierre Sauvant‐Rochat, Michèle Tremblay, Bruno Le Bizec, Marie‐Louise Scippo, Pierre‐Marie Badot, Marie‐Yasmine Bottein, Rachida Chekri, Christine Demeilliers, Virginie Desvignes, Erwan Engel, Gautier Eppe, Anne‐Sophie Ficheux, Eric Houdeau, Emilie Lance, Olivier Laprevote, Michel Laurentie, Ludovic Le Hegarat, Jean‐Charles Leblanc, Nicolas Loiseau, David Makowski, Francesca Mancini, Eric Marchioni, Jean‐François Masfaraud, Mathilde Munier, Isabelle Oswald, Anne Platel, Yann Sivry, Paule Vasseur, Estelle Checlair‐Westerberg, Eléonore Ney, Nathalie Arnich, Carole Catastini   +73 more
wiley   +1 more source

Pnictogen-bonding catalysis: brevetoxin-type polyether cyclizations

Chemical Science, 2020
This study marks chemical space available for pnictogen-bonding catalysis, and demonstrates that reactivity accessible in this space is unique.
Andrea E. Gini, Miguel Paraja, Bartomeu Galmés, C. Besnard, Amalia I. Poblador-Bahamonde, N. Sakai, A. Frontera, S. Matile   +7 more
semanticscholar   +1 more source

Further Insights into Brevetoxin Metabolism by de Novo Radiolabeling

Toxins, 2014
The toxic dinoflagellate Karenia brevis, responsible for early harmful algal blooms in the Gulf of Mexico, produces many secondary metabolites, including potent neurotoxins called brevetoxins (PbTx).
Kevin Calabro, Jean-Marie Guigonis, Jean-Louis Teyssié, François Oberhänsli, Jean-Pierre Goudour, Michel Warnau, Marie-Yasmine Dechraoui Bottein, Olivier P. Thomas   +7 more
doaj   +1 more source

Metabolomics Approach to Reveal the Effects of Ocean Acidification on the Toxicity of Harmful Microalgae: A Review of the Literature

AppliedChem, 2023
Climate change has been associated with intensified harmful algal blooms (HABs). Some harmful microalgae produce toxins that accumulate in food webs, adversely affecting the environment, public health and economy.
Tsz-Ki Victoria Tsui, Hang-Kin Kong
doaj   +1 more source

Impact of Hurricane Ian (2022) on Karenia brevis Bloom on the West Florida Shelf

Geophysical Research Letters, Volume 52, Issue 6, 28 March 2025.
Abstract Blooms of toxigenic Karenia brevis are a major concern to public health and marine ecosystems on the West Florida Shelf. Hurricanes and tropical storms can discharge huge amounts of terrestrial nutrients into coastal oceans over a short time and have been linked to large plankton blooms, but the underlying mechanisms for the bloom generation ...
Yuren Chen, Ming Li
wiley   +1 more source

Fish Sludge as Feed in Circular Bioproduction: Overview of Biological and Chemical Hazards in Fish Sludge and Their Potential Fate via Ingestion by Invertebrates

Reviews in Aquaculture, Volume 17, Issue 1, January 2025.
This review provides knowledge of the biosecurity risks of using fish sludge to produce novel feed ingredients from low‐trophic, extractive animal species in circular value chains. The review includes nutritional composition, sludge treatment practices, EU regulations, and the fate of microbial and chemical hazards contained in sludge till raw ...
Kristin S. Pettersen, Veronika Sele, Pedro Araujo, Ikram Belghit, Sylvie L. Benestad, Aksel Bernhoft, Andy M. Booth, Gunnar S. Eriksen, Julia Farkas, Aleksander H. Handå, Bjørn Henrik Hansen, Kari O. Helgesen, Arne Holst‐Jensen, Gro S. Johannessen, Nina S. Liland, Anne‐Katrine Lundebye, Arne M. Malzahn, Hanne Nilsen, Tom S. Nordtvedt, Madelaine Norström, Magdalena M. Owczarek‐Kościelniak, Øivind Øines, Sonal J. Patel, Hilde Sindre, Inger B. Standal, Andreas Hagemann   +25 more
wiley   +1 more source

Effectors of thioredoxin reductase: Brevetoxins and manumycin-A

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2019
The activities of two effectors, brevetoxin (PbTx) and manumycin-A (Man-A), of thioredoxin reductase (TrxR) have been evaluated against a series of fourteen TrxR orthologs originating from mammals, insects and protists and several mutants. Man-A, a molecule with numerous electrophilic sites, forms a covalent adduct with most selenocystine (Sec ...
Anupama, Tuladhar, Robert J, Hondal, Ricardo, Colon, Elyssa L, Hernandez, Kathleen S, Rein   +4 more
openaire   +3 more sources