A New Cytotoxicity Assay for Brevetoxins Using Fluorescence Microscopy
Marine Drugs, 2014 Brevetoxins are a family of ladder-framed polyether toxins produced during blooms of the marine dinoflagellate, Karenia brevis. Consumption of shellfish or finfish exposed to brevetoxins can lead to the development of neurotoxic shellfish poisoning.
Andrea J Bourdelais
exaly +4 more sources
Immune Modulating Brevetoxins: Monocyte Cytotoxicity, Apoptosis, and Activation of M1/M2 Response Elements Is Dependent on Reactive Groups [PDF]
Marine Drugs, 2022 Brevetoxins are a suite of marine neurotoxins that activate voltage-gated sodium channels (VGSCs) in cell membranes, with toxicity occurring from persistent activation of the channel at high doses.
Jennifer R. McCall +4 more
doaj +3 more sources
Predicting Karenia brevis Induced Respiratory Irritation at Individual Southwest Florida Beaches Using Cell Abundances Plus Wind Direction and Speed [PDF]
GeoHealthNearly annually, blooms of the dinoflagellate Karenia brevis form along the southwest Florida coast leading to a variety of negative impacts, including respiratory irritation (RI) in humans.
K. M. Collins +6 more
doaj +3 more sources
Brevetoxin versus Brevenal Modulation of Human Nav1 Channels [PDF]
Marine Drugs, 2023 Brevetoxins (PbTx) and brevenal are marine ladder-frame polyethers. PbTx binds to and activates voltage-gated sodium (Nav) channels in native tissues, whereas brevenal antagonizes these actions.
Rocio K. Finol-Urdaneta +3 more
doaj +2 more sources
Marine Drugs, 2021 In France, four groups of lipophilic toxins are currently regulated: okadaic acid/dinophysistoxins, pectenotoxins, yessotoxins and azaspiracids. However, many other families of toxins exist, which can be emerging toxins.
Zouher Amzil +2 more
exaly +3 more sources
Guidance Level for Brevetoxins in French Shellfish [PDF]
Marine Drugs, 2021 Brevetoxins (BTXs) are marine biotoxins responsible for neurotoxic shellfish poisoning (NSP) after ingestion of contaminated shellfish. NSP is characterized by neurological, gastrointestinal and/or cardiovascular symptoms. The main known producer of BTXs
Nathalie Arnich +10 more
doaj +6 more sources
Five Years Monitoring the Emergence of Unregulated Toxins in Shellfish in France (EMERGTOX 2018–2022) [PDF]
Marine Drugs, 2023 Shellfish accumulate microalgal toxins, which can make them unsafe for human consumption. In France, in accordance with EU regulations, three groups of marine toxins are currently under official monitoring: lipophilic toxins, saxitoxins, and domoic acid.
Zouher Amzil +10 more
doaj +2 more sources
Development of a New Monoclonal Antibody against Brevetoxins in Oyster Samples Based on the Indirect Competitive Enzyme-Linked Immunosorbent Assay [PDF]
Foods, 2021 The consumption of shellfish contaminated with brevetoxins, a family of ladder-frame polyether toxins formed during blooms of the marine dinoflagellate Karenia brevis, can cause neurotoxic poisoning, leading to gastroenteritis and neurotoxic effects.
Xiya Zhang +8 more
doaj +2 more sources
Chemodiversity of Brevetoxins and Other Potentially Toxic Metabolites Produced by Karenia spp. and Their Metabolic Products in Marine Organisms [PDF]
Marine Drugs, 2021 In recent decades, more than 130 potentially toxic metabolites originating from dinoflagellate species belonging to the genus Karenia or metabolized by marine organisms have been described.
Vincent Hort +4 more
doaj +2 more sources
Exposure to the Florida red tide dinoflagellate, Karenia brevis, and its associated brevetoxins induces ecophysiological and proteomic alterations in Porites astreoides. [PDF]
PLoS ONE, 2020 As reef-building corals are increasingly being exposed to persistent threats that operate on both regional and global scales, there is a pressing need to better understand the complex processes that diminish coral populations. This study investigated the
David A Reynolds +3 more
doaj +1 more source