Comparative Quantitative Proteomic Analysis of High and Low Toxin-Producing Karenia brevis Strains Reveals Differences in Polyketide Synthase Abundance and Redox Status of the Proteome [PDF]
Marine DrugsTo identify differentially abundant polyketide synthases (PKSs) and to characterize the biochemical consequences of brevetoxin biosynthesis, bottom-up, TMT-based quantitative proteomics and redox proteomics were conducted to compare two strains of the ...
Kathleen S. Rein +5 more
doaj +2 more sources
Immune Modulating Brevetoxins: Monocyte Cytotoxicity, Apoptosis, and Activation of M1/M2 Response Elements Is Dependent on Reactive Groups [PDF]
Marine Drugs, 2022 Brevetoxins are a suite of marine neurotoxins that activate voltage-gated sodium channels (VGSCs) in cell membranes, with toxicity occurring from persistent activation of the channel at high doses.
Jennifer R. McCall +4 more
doaj +2 more sources
Brevetoxin Metabolites: Emerging Toxins in French Shellfish Determined by LC-MS/MS and ELISA [PDF]
Marine DrugsIn France, as part of the monitoring program for the emergence of marine toxins in shellfish (EMERGTOX), brevetoxins (BTX-2, BTX-3) were first detected in shellfish from Corsica (Mediterranean Sea) in 2018.
Zouher Amzil +4 more
doaj +2 more sources
Brevetoxin versus Brevenal Modulation of Human Nav1 Channels [PDF]
Marine Drugs, 2023 Brevetoxins (PbTx) and brevenal are marine ladder-frame polyethers. PbTx binds to and activates voltage-gated sodium (Nav) channels in native tissues, whereas brevenal antagonizes these actions.
Rocio K. Finol-Urdaneta +3 more
doaj +2 more sources
Brevetoxin Dynamics and Bioavailability from Floc Following PAC-Modified Clay Treatment of Karenia brevis Blooms [PDF]
ToxinsHarmful algal blooms (HABs) caused by the dinoflagellate Karenia brevis present serious ecological and public health concerns due to the production of brevetoxins (BTX).
Nicholas R. Ohnikian +8 more
doaj +2 more sources
Emerging Insights into Brevetoxicosis in Sea Turtles [PDF]
AnimalsThis review summarizes the current understanding of how brevetoxins, produced by Karenia brevis during harmful algal blooms, impact sea turtle health.
Remco A. Nederlof +5 more
doaj +2 more sources
Brevetoxin Aptamer Selection and Biolayer Interferometry Biosensor Application [PDF]
ToxinsBrevetoxins (PbTxs) are very potent marine neurotoxins that can cause an illness clinically described as neurologic shellfish poisoning (NSP). These toxins are cyclic polyether in chemistry and have increased their geographical distribution in the past 2
Bo Hu +8 more
doaj +2 more sources
The Effects of the Harmful Algal Bloom Species Karenia brevis on Survival of Red Porgy (Pagrus pagrus) Larvae [PDF]
Toxins, 2022 The harmful algal bloom species, Karenia brevis, forms annual, often intense blooms in the Gulf of Mexico, particularly along the west Florida shelf. Though the ability of K.
Richard Wayne Litaker +5 more
doaj +2 more sources
Brevetoxin PbTx2 Modulates Oxidative Stress and Inflammatory Response in an In Vitro Human Immune Cell Line [PDF]
ToxicsBrevetoxins (PbTx) exert detrimental effects on marine organisms and humans, mainly through alterations in immune cell function. This study evaluated the immunotoxic potential of sublethal concentrations of PbTx-2 using the THP-1 human monocyte cell line
Ambbar Aballay-González +6 more
doaj +2 more sources
Acute Effects of Brevetoxin-3 Administered via Oral Gavage to Mice [PDF]
Marine Drugs, 2023 Brevetoxins (BTXs) constitute a family of lipid-soluble toxic cyclic polyethers mainly produced by Karenia brevis, which is the main vector for a foodborne syndrome known as neurotoxic shellfish poisoning (NSP) in humans.
Peggy Barbe +6 more
doaj +2 more sources