Results 41 to 50 of about 1,082 (163)

Brevetoxin and Conotoxin Interactions with Single-Domain Voltage-Gated Sodium Channels from a Diatom and Coccolithophore

Marine Drugs, 2021
The recently characterized single-domain voltage-gated ion channels from eukaryotic protists (EukCats) provide an array of novel channel proteins upon which to test the pharmacology of both clinically and environmentally relevant marine toxins.
Ping Yates, Julie A. Koester, Alison R. Taylor   +2 more
doaj   +1 more source

Comparative analysis of three brevetoxin-associated bottlenose dolphin (Tursiops truncatus) mortality events in the Florida Panhandle region (USA).

PLoS ONE, 2012
In the Florida Panhandle region, bottlenose dolphins (Tursiops truncatus) have been highly susceptible to large-scale unusual mortality events (UMEs) that may have been the result of exposure to blooms of the dinoflagellate Karenia brevis and its ...
Michael J Twiner, Leanne J Flewelling, Spencer E Fire, Sabrina R Bowen-Stevens, Joseph K Gaydos, Christine K Johnson, Jan H Landsberg, Tod A Leighfield, Blair Mase-Guthrie, Lori Schwacke, Frances M Van Dolah, Zhihong Wang, Teresa K Rowles   +12 more
doaj   +1 more source

First Light Demonstration of Red Solar Induced Fluorescence for Harmful Algal Bloom Monitoring

Geophysical Research Letters, Volume 50, Issue 13, 16 July 2023., 2023
Abstract The risks harmful algal blooms (HAB) pose to aquatic ecosystems, public health, and coastal economies necessitate supplementation of current observation strategies. Herein, we explore the use of red solar induced fluorescence (SIF) from the TROPOspheric Monitoring Instrument (TROPOMI), a remote sensing measurement retrievable in variable cloud
Kelly Luis, Philipp Köhler, Christian Frankenberg, Michelle Gierach   +3 more
wiley   +1 more source

Molecular Determinants of Brevetoxin Binding to Voltage-Gated Sodium Channels

Toxins, 2019
Brevetoxins are produced by dinoflagellates such as Karenia brevis in warm-water red tides and cause neurotoxic shellfish poisoning. They bind to voltage-gated sodium channels at neurotoxin receptor 5, making the channels more active by shifting the ...
Keiichi Konoki, Daniel G. Baden, Todd Scheuer, William A. Catterall   +3 more
doaj   +1 more source

Metabarcoding analysis identifies high diversity of harmful algal bloom species in the coastal waters of the Beibu Gulf

Ecology and Evolution, Volume 13, Issue 5, May 2023., 2023
This study firstly combined both short‐read and long‐read metabarcoding analyses for annual marine phytoplankton community and harmful algal bloom species identification in the Beibu Gulf. Based on the high richness from short‐read and the high accuracy of species identification from long‐read, HAB species with high diversity and abundance were ...
Liyan He, Zhiming Yu, Xin Xu, Jianan Zhu, Yongquan Yuan, Xihua Cao, Xiuxian Song   +6 more
wiley   +1 more source

Concurrent exposure of bottlenose dolphins (Tursiops truncatus) to multiple algal toxins in Sarasota Bay, Florida, USA.

PLoS ONE, 2011
Sentinel species such as bottlenose dolphins (Tursiops truncatus) can be impacted by large-scale mortality events due to exposure to marine algal toxins.
Michael J Twiner, Spencer Fire, Lori Schwacke, Leigh Davidson, Zhihong Wang, Steve Morton, Stephen Roth, Brian Balmer, Teresa K Rowles, Randall S Wells   +9 more
doaj   +1 more source

Calcium Increase and Substance P Release Induced by the Neurotoxin Brevetoxin-1 in Sensory Neurons: Involvement of PAR2 Activation through Both Cathepsin S and Canonical Signaling

Cells, 2020
Red tides involving Karenia brevis expose humans to brevetoxins (PbTxs). Oral exposition triggers neurotoxic shellfish poisoning, whereas inhalation induces a respiratory syndrome and sensory disturbances.
Ophélie Pierre, Maxime Fouchard, Paul Buscaglia, Nelig Le Goux, Raphaël Leschiera, Olivier Mignen, Joachim W. Fluhr, Laurent Misery, Raphaële Le Garrec   +8 more
doaj   +1 more source

Spectroscopic ellipsometry methods for brevetoxin detection

Talanta, 2022
The spectroscopic ellipsometry (SE), and attenuated internal reflection spectroscopic ellipsometry (TIRE) are promising methods in label-free biosensing applications. An ellipsometer running under surface plasmon resonance (SPR) conditions has unique advantages over other SPR-based methods in terms of sensitivity and real-time/label-free measurement ...
Mustafa Oguzhan Caglayan, Zafer Üstündağ, Samet Şahin   +2 more
openaire   +2 more sources

Synthesis, Modeling, and Biological Evaluation of Analogues of the Semisynthetic Brevetoxin Antagonist β‐Naphthoyl‐Brevetoxin [PDF]

ChemBioChem, 2007
AbstractBrevetoxins are neurotoxic compounds produced by the dinoflagellate Karenia brevis. Extensive blooms induce neurotoxic shellfish poisoning (NSP) and asthma‐like symptoms in humans. β‐naphthoyl‐brevetoxin, the first semisynthetic brevetoxin antagonist, has been defined as the lead compound in the investigation of the mechanisms of ...
Sophie, Michelliza, William M, Abraham, Henry M, Jacocks, Thomas, Schuster, Daniel G, Baden   +4 more
openaire   +2 more sources

Structure Activity Relationship of Brevenal Hydrazide Derivatives

Marine Drugs, 2014
Brevenal is a ladder frame polyether produced by the dinoflagellate Karenia brevis. This organism is also responsible for the production of the neurotoxic compounds known as brevetoxins. Ingestion or inhalation of the brevetoxins leads to adverse effects
Allan Goodman, Jennifer R. McCall, Henry M. Jacocks, Alysha Thompson, Daniel Baden, William M. Abraham, Andrea Bourdelais   +6 more
doaj   +1 more source