Results 61 to 70 of about 1,082 (163)
Toxins, 2023 Algal toxins pose a serious threat to human and coastal ecosystem health, even if their potential impacts are poorly documented in New Caledonia (NC).
Manoëlla Sibat +5 more
doaj +1 more source
Interaction of a dinoflagellate neurotoxin with voltage-activated ion channels in a marine diatom [PDF]
PeerJ, 2018 Background The potent neurotoxins produced by the harmful algal bloom species Karenia brevis are activators of sodium voltage-gated channels (VGC) in animals, resulting in altered channel kinetics and membrane hyperexcitability.
Sheila A. Kitchen +2 more
doaj +2 more sources
Toxicon, 1992 The marine toxins known generically as brevetoxins, as well as their structural relative ciguatoxin, are known as polyether ladder toxins, and bind uniquely to site 5 of the voltage-sensitive sodium channel. Rat brain synaptosome binding data show similarities in binding affinity for brevetoxins having the same structural (ladder) backbone, but ...
R E, Gawley +3 more
openaire +2 more sources
Total Synthesis of Brevetoxin B [PDF]
ChemInform, 2007 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Kadota, Isao, Takamura, Hiroyoshi
openaire +2 more sources
Limnology and Oceanography: Methods, Volume 24, Issue 1, January 2026.Abstract Curcumin, a natural plant product derived from Curcuma longa, was assessed as a mitigation technique against the toxic bloom‐forming dinoflagellate Karenia brevis in two mesocosm experiments taking place in 2022 and 2024. In these experiments, curcumin was applied at a dosage of 5 mg L−1 to K.
Victoria Devillier +6 more
wiley +1 more source
A New Cytotoxicity Assay for Brevetoxins Using Fluorescence Microscopy
Marine Drugs, 2014 Brevetoxins are a family of ladder-framed polyether toxins produced during blooms of the marine dinoflagellate, Karenia brevis. Consumption of shellfish or finfish exposed to brevetoxins can lead to the development of neurotoxic shellfish poisoning.
Jennifer R. McCall +2 more
doaj +1 more source
An ecological framework for microbial metabolites in the ocean ecosystem
Limnology and Oceanography Letters, Volume 10, Issue 5, Page 636-659, September 2025.Abstract The ocean microbe‐metabolite network involves thousands of individual metabolites that encompass a breadth of chemical diversity and biological functions. These microbial metabolites mediate biogeochemical cycles, facilitate ecological relationships, and impact ecosystem health. While analytical advancements have begun to illuminate such roles,
Bryndan P. Durham +24 more
wiley +1 more source
Die Chemie und Biologie der Tetrodotoxin Naturstofffamilie
Angewandte Chemie, Volume 137, Issue 35, August 25, 2025.Tetrodotoxin ist vor allem als das Gift des Kugelfisches bekannt, einer Delikatesse in der japanischen Küche. Seine Toxizität beruht auf der selektiven Blockade von NaV Kanälen, wie am Beispiel der NaV1.7 Pore dargestellt, wobei das DEKA Motiv hervorgehoben ist, das für die Durchlässigkeit von Natriumionen verantwortlich ist.
Benedikt Nißl +6 more
wiley +1 more source
Marine Drugs, 2022 N-methyl-D-aspartate (NMDA) receptors play a critical role in activity-dependent dendritic arborization, spinogenesis, and synapse formation by stimulating calcium-dependent signaling pathways.
Suneet Mehrotra +3 more
doaj +1 more source
The Chemistry and Biology of the Tetrodotoxin Natural Product Family
Angewandte Chemie International Edition, Volume 64, Issue 35, August 25, 2025.Tetrodotoxin is best known as the poison of the pufferfish, which is a delicacy in Japanese cuisine. Its toxicity arises from the selective blockage of NaV channels, which is depicted for the NaV1.7 pore, highlighting the DEKA motif, which permeates sodium ions.
Benedikt Nißl +6 more
wiley +1 more source