Results 61 to 70 of about 1,538 (200)

Lessons learned from mesocosm experiments with curcumin: Pilot studies of a harmful algal bloom mitigation technique

Limnology and Oceanography: Methods, Volume 24, Issue 1, January 2026.
Abstract Curcumin, a natural plant product derived from Curcuma longa, was assessed as a mitigation technique against the toxic bloom‐forming dinoflagellate Karenia brevis in two mesocosm experiments taking place in 2022 and 2024. In these experiments, curcumin was applied at a dosage of 5 mg L−1 to K.
Victoria Devillier, Emily R. Hall, Cynthia A. Heil, Jessica D. Frankle, Sarah Klass, Jennifer H. Toyoda, Rich Pierce   +6 more
wiley   +1 more source

Total Synthesis of Brevetoxin-B

, 2016
Brevetoxin-B (BTX-B), produced by the red tide organism, Gymnodium breve Davis, is the first member of marine polycyclic ethers to be structurally elucidated and one of the most potent neurotoxins. The structural feature is a trans-fused polycyclic ether
Goh Matsuo (2702941), Hiroko Matsukura (2702944), Tadashi Nakata (2103187), Nobuyuki Hori (2702938), Koji Kawamura (145204)   +4 more
core   +3 more sources

A New Cytotoxicity Assay for Brevetoxins Using Fluorescence Microscopy

Marine Drugs, 2014
Brevetoxins are a family of ladder-framed polyether toxins produced during blooms of the marine dinoflagellate, Karenia brevis. Consumption of shellfish or finfish exposed to brevetoxins can lead to the development of neurotoxic shellfish poisoning.
Jennifer R. McCall, Elizabeth A. Elliott, Andrea J. Bourdelais   +2 more
doaj   +1 more source

Binding of brevetoxins and ciguatoxin to the voltage-sensitive sodium channel and conformational analysis of brevetoxin B

Toxicon, 1992
The marine toxins known generically as brevetoxins, as well as their structural relative ciguatoxin, are known as polyether ladder toxins, and bind uniquely to site 5 of the voltage-sensitive sodium channel. Rat brain synaptosome binding data show similarities in binding affinity for brevetoxins having the same structural (ladder) backbone, but ...
R E, Gawley, K S, Rein, M, Kinoshita, D G, Baden   +3 more
openaire   +2 more sources

An ecological framework for microbial metabolites in the ocean ecosystem

Limnology and Oceanography Letters, Volume 10, Issue 5, Page 636-659, September 2025.
Abstract The ocean microbe‐metabolite network involves thousands of individual metabolites that encompass a breadth of chemical diversity and biological functions. These microbial metabolites mediate biogeochemical cycles, facilitate ecological relationships, and impact ecosystem health. While analytical advancements have begun to illuminate such roles,
Bryndan P. Durham, Winifred M. Johnson, Catherine C. Bannon, Erin M. Bertrand, Anitra E. Ingalls, Bethanie R. Edwards, Amy Apprill, Angela K. Boysen, Randelle M. Bundy, Huan Chen, Frank X. Ferrer‐González, Cara Fiore, Katherine R. Heal, Constanze Kuhlisch, Shuting Liu, Kaijun Lu, Laurel E. Meke, Sammy Pontrelli, Prabavathy Vaiyapuri Ramalingam, Alicia M. Reigel, Joshua S. Sacks, Jeremy E. Schreier, Jegan Sekar, Mario Uchimiya, Elizabeth B. Kujawinski   +24 more
wiley   +1 more source

Effectors of thioredoxin reductase: Brevetoxins and manumycin-A

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2019
The activities of two effectors, brevetoxin (PbTx) and manumycin-A (Man-A), of thioredoxin reductase (TrxR) have been evaluated against a series of fourteen TrxR orthologs originating from mammals, insects and protists and several mutants. Man-A, a molecule with numerous electrophilic sites, forms a covalent adduct with most selenocystine (Sec ...
Anupama, Tuladhar, Robert J, Hondal, Ricardo, Colon, Elyssa L, Hernandez, Kathleen S, Rein   +4 more
openaire   +3 more sources

Die Chemie und Biologie der Tetrodotoxin Naturstofffamilie

Angewandte Chemie, Volume 137, Issue 35, August 25, 2025.
Tetrodotoxin ist vor allem als das Gift des Kugelfisches bekannt, einer Delikatesse in der japanischen Küche. Seine Toxizität beruht auf der selektiven Blockade von NaV Kanälen, wie am Beispiel der NaV1.7 Pore dargestellt, wobei das DEKA Motiv hervorgehoben ist, das für die Durchlässigkeit von Natriumionen verantwortlich ist.
Benedikt Nißl, Marcel Mülbaier, Francesca Grisoni, Dirk Trauner, Marcel Bermúdez, Clemens Dialer, David B. Konrad   +6 more
wiley   +1 more source

Stimulation of Neurite Outgrowth in Cerebrocortical Neurons by Sodium Channel Activator Brevetoxin-2 Requires Both N-Methyl-D-aspartate Receptor 2B (GluN2B) and p21 Protein (Cdc42/Rac)-Activated Kinase 1 (PAK1)

Marine Drugs, 2022
N-methyl-D-aspartate (NMDA) receptors play a critical role in activity-dependent dendritic arborization, spinogenesis, and synapse formation by stimulating calcium-dependent signaling pathways.
Suneet Mehrotra, Marsha L. Pierce, Shashank M. Dravid, Thomas F. Murray   +3 more
doaj   +1 more source

The Chemistry and Biology of the Tetrodotoxin Natural Product Family

Angewandte Chemie International Edition, Volume 64, Issue 35, August 25, 2025.
Tetrodotoxin is best known as the poison of the pufferfish, which is a delicacy in Japanese cuisine. Its toxicity arises from the selective blockage of NaV channels, which is depicted for the NaV1.7 pore, highlighting the DEKA motif, which permeates sodium ions.
Benedikt Nißl, Marcel Mülbaier, Francesca Grisoni, Dirk Trauner, Marcel Bermúdez, Clemens Dialer, David B. Konrad   +6 more
wiley   +1 more source

Development of a Rapid Throughput Assay for Identification of hNav1.7 Antagonist Using Unique Efficacious Sodium Channel Agonist, Antillatoxin

Marine Drugs, 2016
Voltage-gated sodium channels (VGSCs) are responsible for the generation of the action potential. Among nine classified VGSC subtypes (Nav1.1–Nav1.9), Nav1.7 is primarily expressed in the sensory neurons, contributing to the nociception transmission ...
Fang Zhao, Xichun Li, Liang Jin, Fan Zhang, Masayuki Inoue, Boyang Yu, Zhengyu Cao   +6 more
doaj   +1 more source