Preparation of Monoclonal Antibody for Brevetoxin 1 and Development of Ic-ELISA and Colloidal Gold Strip to Detect Brevetoxin 1 [PDF]
Toxins, 2018 Brevetoxin-1 (BTX-1), a marine toxin mostly produced by the dinoflagellatae Karenia brevis, has caused the death of marine organisms and has had numerous toxicological effects on human health.
Sumei Ling +8 more
doaj +5 more sources
Molecular Determinants of Brevetoxin Binding to Voltage-Gated Sodium Channels
Toxins, 2019 Brevetoxins are produced by dinoflagellates such as Karenia brevis in warm-water red tides and cause neurotoxic shellfish poisoning. They bind to voltage-gated sodium channels at neurotoxin receptor 5, making the channels more active by shifting the ...
Keiichi Konoki +3 more
doaj +2 more sources
Total Synthesis of Brevetoxin A [PDF]
Organic Letters, 2008 A total synthesis of brevetoxin A is reported. Two tetracyclic coupling partners, prepared from previously reported advanced fragments, were effectively united via a Horner—Wittig olefination. The resulting octacycle was progressed to substrates that were explored for reductive etherification, the success of which led to a penultimate tetraol ...
Michael T, Crimmins +6 more
openaire +4 more sources
Journal of Marine Science and Engineering, 2019 Spherical cells were detected in low salinity waters during a bloom of Karenia brevis in Alabama coastal waters. These balls resembled K. brevis in size and organelle appearance, contained similar concentration of brevetoxin, and occurred during ongoing ...
Lucie Novoveská, Alison Robertson
doaj +2 more sources
Comparative analysis of three brevetoxin-associated bottlenose dolphin (Tursiops truncatus) mortality events in the Florida Panhandle region (USA). [PDF]
PLoS ONE, 2012 In the Florida Panhandle region, bottlenose dolphins (Tursiops truncatus) have been highly susceptible to large-scale unusual mortality events (UMEs) that may have been the result of exposure to blooms of the dinoflagellate Karenia brevis and its ...
Michael J Twiner +12 more
doaj +2 more sources
Determination of brevetoxin in recent marine sediments [PDF]
Chemosphere, 2008 Harmful algal blooms (HAB) of Karenia brevis (K. brevis) produce a suite of lipid soluble polyether brevetoxins, known to cause environmental, health and economic ill effects. There is evidence that K. brevis has increased in abundance over the past 50 years, but the dataset is incomplete.
Wilson G, Mendoza +3 more
openaire +3 more sources
A Highly Convergent Approach to Brevetoxin A
Organic Letters, 2007 Through optimized, scaled-up routes to the G and J rings of brevetoxin A, a convergent strategy based upon a Horner-Wadsworth-Emmons coupling reaction completed the GHIJ fragment. Further studies toward an alternative protecting group strategy for the GHIJ fragment elucidated a shortened synthesis.
Michael T, Crimmins +3 more
core +5 more sources
“Algal-dromes”: a novel conceptual approach to illness in humans exposed to harmful algal bloom toxins [PDF]
Frontiers in ToxicologyAlthough adverse health effects from harmful algal bloom (HAB) toxins have been described since antiquity, the true worldwide incidence and disease burden has yet to be defined.
Brett Johnson +4 more
doaj +2 more sources
Chemiluminescent Receptor Binding Assay for Ciguatoxins and Brevetoxins Using Acridinium Brevetoxin-B2 [PDF]
Toxins, 2019 Ciguatera is the term for poisoning resulting from eating fish from tropical or subtropical regions. The causative toxins collectively named ciguatoxins (CTXs) widely differ in structures depending on their geographic origins, which range from the ...
Kazuya Murata, Takeshi Yasumoto
doaj +3 more sources
Design of a Duplex-to-Complex Structure-Switching Approach for the Homogeneous Determination of Marine Biotoxins in Water [PDF]
ToxinsIn this report, we describe a fluorescent assay for the detection of six marine toxins in water. The mechanism of detection is based on a duplex-to-complex structure-switching approach.
Awatef Al-Tabban +5 more
doaj +2 more sources