Results 151 to 160 of about 1,538 (200)
Targeting STAT3 in systemic lupus erythematosus and lupus nephritis: mechanisms, therapeutic advances, and structure-informed perspectives. [PDF]
Front PharmacolYi F +10 more
europepmc +1 more source
Marine Algal Toxins and Public Health: Insights from Shellfish and Fish, the Main Biological Vectors. [PDF]
Mar DrugsYuan KK, Li HY, Yang WD.
europepmc +1 more source
Establishing Detection Methods for Okadaic Acid Aptamer-Target Interactions: Insights from Computational and Experimental Approaches. [PDF]
FoodsShan W, Sun J, Liu R, Wang J, Shao B.
europepmc +1 more source
Brevetoxin derivatives that inhibit toxin activity [PDF]
Chemistry and Biology, 2000 The brevetoxins are marine neurotoxins that interfere with the normal functions of the voltage-gated Na(+) channel. We have identified two brevetoxin derivatives that do not exhibit pharmacological properties typical of the brevetoxins and that function as brevetoxin antagonists.PbTx-3 and benzoyl-PbTx-3 elicited Na(+) channel openings during steady ...
Lynne A Fieber +2 more
exaly +4 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Antibodies to brevetoxin B: Serologic differentiation of brevetoxin B and brevetoxin A
Toxicon, 1992A brevetoxin B immunogen was prepared by reacting brevetoxin B with the amino groups of bovine albumin followed by treatment with sodium borohydride. Immunized rabbits produced antibodies that bound [3H]brevetoxin B-alcohol. This binding increased with repeated immunization (KD for one rabbit after three courses of immunization was about 10 pM ...
L, Levine, Y, Shimizu
openaire +2 more sources
2000
Abstract Brevetoxins are lipid-soluble marine poisons synthesized by the red tide dinoflagellate Ptychodiscus brevis (previously Gymnodinium breve). These cyclic polyethers and structural relatives of ciguatoxin may induce massive killings of fish and also cause neurotoxic shell fish poisoning (NSP). NSP is a nonlethal intoxication of
Baden, Daniel G., Adams, David J.
openaire +3 more sources
Abstract Brevetoxins are lipid-soluble marine poisons synthesized by the red tide dinoflagellate Ptychodiscus brevis (previously Gymnodinium breve). These cyclic polyethers and structural relatives of ciguatoxin may induce massive killings of fish and also cause neurotoxic shell fish poisoning (NSP). NSP is a nonlethal intoxication of
Baden, Daniel G., Adams, David J.
openaire +3 more sources
Total synthesis of brevetoxin A
Nature, 1998Brevetoxin A is the most potent neurotoxin secreted by Gymnodinium breve Davis, a marine organism often associated with harmful algal blooms known as 'red tides'. The compound, whose mechanism of action involves binding to and opening of sodium channels, is sufficiently toxic to kill fish at concentrations of nanograms per ml and, after accumulation in
K C, Nicolaou +5 more
openaire +2 more sources
Cardiovascular effects of brevetoxins in dogs
Toxicon, 1985In anesthetized spontaneously breathing dogs, brevetoxin caused dose-dependent periods of apnea and, at high doses, respiratory arrest. In artificially ventilated dogs, i.v. brevetoxin caused complex dose-related cardiovascular changes consisting of: (1) bradycardia; (2) triphasic blood pressure changes, sequentially characterized by depressor/pressor ...
G L, Johnson, J J, Spikes, S, Ellis
openaire +2 more sources
Total Synthesis of Brevetoxin B
Journal of the American Chemical Society, 2005The convergent total synthesis of brevetoxin B (1) has been achieved. The intramolecular allylation of the O,S-acetal 20, prepared from the alpha-chlorosulfide 17 and the alcohol 5, was carried out using AgOTf as a Lewis acid to give the diene 21, predominantly.
Isao, Kadota +3 more
openaire +2 more sources