Results 11 to 20 of about 2,771 (230)

Brevetoxin Metabolites: Emerging Toxins in French Shellfish Determined by LC-MS/MS and ELISA. [PDF]

Mar Drugs
In France, as part of the monitoring program for the emergence of marine toxins in shellfish (EMERGTOX), brevetoxins (BTX-2, BTX-3) were first detected in shellfish from Corsica (Mediterranean Sea) in 2018.
Amzil Z, Derrien A, Lhaute K, Terrillon AT, Tanniou S.   +4 more
europepmc   +4 more sources

Brevetoxin Dynamics and Bioavailability from Floc Following PAC-Modified Clay Treatment of Karenia brevis Blooms. [PDF]

Toxins (Basel)
Harmful algal blooms (HABs) caused by the dinoflagellate Karenia brevis present serious ecological and public health concerns due to the production of brevetoxins (BTX).
Ohnikian NR, Sibley CD, Freiberger RB, Buck KN, Myers A, Harlow S, Anderson DM, Pierce R, Toyoda JH.   +8 more
europepmc   +3 more sources

Brevetoxin versus Brevenal Modulation of Human Nav1 Channels. [PDF]

Mar Drugs, 2023
Brevetoxins (PbTx) and brevenal are marine ladder-frame polyethers. PbTx binds to and activates voltage-gated sodium (Nav) channels in native tissues, whereas brevenal antagonizes these actions.
Finol-Urdaneta RK, Zhorov BS, Baden DG, Adams DJ.   +3 more
europepmc   +3 more sources

Molecular Determinants of Brevetoxin Binding to Voltage-Gated Sodium Channels

Toxins, 2019
Brevetoxins are produced by dinoflagellates such as Karenia brevis in warm-water red tides and cause neurotoxic shellfish poisoning. They bind to voltage-gated sodium channels at neurotoxin receptor 5, making the channels more active by shifting the ...
Keiichi Konoki, Daniel G. Baden, Todd Scheuer, William A. Catterall   +3 more
doaj   +3 more sources

Brevetoxin Aptamer Selection and Biolayer Interferometry Biosensor Application. [PDF]

Toxins (Basel)
Brevetoxins (PbTxs) are very potent marine neurotoxins that can cause an illness clinically described as neurologic shellfish poisoning (NSP). These toxins are cyclic polyether in chemistry and have increased their geographical distribution in the past 2
Hu B, Ouyang SQ, Zhu YP, Lu XL, Ning Z, Jiao BH, Wang LH, Yu HB, Liu XY.   +8 more
europepmc   +3 more sources

Brevetoxin derivatives that inhibit toxin activity [PDF]

Chemistry and Biology, 2000
The brevetoxins are marine neurotoxins that interfere with the normal functions of the voltage-gated Na(+) channel. We have identified two brevetoxin derivatives that do not exhibit pharmacological properties typical of the brevetoxins and that function as brevetoxin antagonists.PbTx-3 and benzoyl-PbTx-3 elicited Na(+) channel openings during steady ...
Kathleen S. Rein, Lynne A. Fieber, Daniel G Baden   +2 more
exaly   +5 more sources

Brevetoxin PbTx2 Modulates Oxidative Stress and Inflammatory Response in an In Vitro Human Immune Cell Line. [PDF]

Toxics
Brevetoxins (PbTx) exert detrimental effects on marine organisms and humans, mainly through alterations in immune cell function. This study evaluated the immunotoxic potential of sublethal concentrations of PbTx-2 using the THP-1 human monocyte cell line
Aballay-González A, Melo C, Rivera A, Martorell M, Ulloa V, Gallardo-Rodriguez JJ, Astuya-Villalón A.   +6 more
europepmc   +3 more sources

Detection of Brevetoxin in Human Plasma by ELISA. [PDF]

J Anal Toxicol, 2022
Abstract Florida red tides have become more common and persistent in and around the Gulf of Mexico. When in bloom, red tides can produce brevetoxins in high concentrations, leading to human exposures primarily through contaminated food and ocean spray.
Cunningham BR, Coleman RM, Schaefer AM, Hamelin EI, Johnson RC.   +4 more
europepmc   +5 more sources

Brevetoxin-Producing Spherical Cells Present in Karenia brevis Bloom: Evidence of Morphological Plasticity?

Journal of Marine Science and Engineering, 2019
Spherical cells were detected in low salinity waters during a bloom of Karenia brevis in Alabama coastal waters. These balls resembled K. brevis in size and organelle appearance, contained similar concentration of brevetoxin, and occurred during ongoing ...
Lucie Novoveská, Alison Robertson
doaj   +3 more sources

Preparation of Monoclonal Antibody for Brevetoxin 1 and Development of Ic-ELISA and Colloidal Gold Strip to Detect Brevetoxin 1

Toxins, 2018
Brevetoxin-1 (BTX-1), a marine toxin mostly produced by the dinoflagellatae Karenia brevis, has caused the death of marine organisms and has had numerous toxicological effects on human health.
Shihua Wang, Shiwei Xiao, Sumei Ling
exaly   +4 more sources