Results 21 to 30 of about 145 (130)
PLoS ONE, 2011 Sentinel species such as bottlenose dolphins (Tursiops truncatus) can be impacted by large-scale mortality events due to exposure to marine algal toxins.
Michael J Twiner +9 more
doaj +1 more source
Brevetoxin versus Brevenal Modulation of Human Nav1 Channels
Marine Drugs, 2023 Brevetoxins (PbTx) and brevenal are marine ladder-frame polyethers. PbTx binds to and activates voltage-gated sodium (Nav) channels in native tissues, whereas brevenal antagonizes these actions.
Rocio K. Finol-Urdaneta +3 more
doaj +1 more source
Cells, 2020 Red tides involving Karenia brevis expose humans to brevetoxins (PbTxs). Oral exposition triggers neurotoxic shellfish poisoning, whereas inhalation induces a respiratory syndrome and sensory disturbances.
Ophélie Pierre +8 more
doaj +1 more source
Toxins, 2022 The harmful algal bloom species, Karenia brevis, forms annual, often intense blooms in the Gulf of Mexico, particularly along the west Florida shelf. Though the ability of K.
Richard Wayne Litaker +5 more
doaj +1 more source
Spectroscopic ellipsometry methods for brevetoxin detection
Talanta, 2022 The spectroscopic ellipsometry (SE), and attenuated internal reflection spectroscopic ellipsometry (TIRE) are promising methods in label-free biosensing applications. An ellipsometer running under surface plasmon resonance (SPR) conditions has unique advantages over other SPR-based methods in terms of sensitivity and real-time/label-free measurement ...
Mustafa Oguzhan Caglayan +2 more
openaire +2 more sources
Synthesis, Modeling, and Biological Evaluation of Analogues of the Semisynthetic Brevetoxin Antagonist β‐Naphthoyl‐Brevetoxin [PDF]
ChemBioChem, 2007 AbstractBrevetoxins are neurotoxic compounds produced by the dinoflagellate Karenia brevis. Extensive blooms induce neurotoxic shellfish poisoning (NSP) and asthma‐like symptoms in humans. β‐naphthoyl‐brevetoxin, the first semisynthetic brevetoxin antagonist, has been defined as the lead compound in the investigation of the mechanisms of ...
Sophie, Michelliza +4 more
openaire +2 more sources
Structure Activity Relationship of Brevenal Hydrazide Derivatives
Marine Drugs, 2014 Brevenal is a ladder frame polyether produced by the dinoflagellate Karenia brevis. This organism is also responsible for the production of the neurotoxic compounds known as brevetoxins. Ingestion or inhalation of the brevetoxins leads to adverse effects
Allan Goodman +6 more
doaj +1 more source
Acute Effects of Brevetoxin-3 Administered via Oral Gavage to Mice
Marine Drugs, 2023 Brevetoxins (BTXs) constitute a family of lipid-soluble toxic cyclic polyethers mainly produced by Karenia brevis, which is the main vector for a foodborne syndrome known as neurotoxic shellfish poisoning (NSP) in humans.
Peggy Barbe +6 more
doaj +1 more source
Brevenal inhibits pacific ciguatoxin-1B-induced neurosecretion from bovine chromaffin cells.
PLoS ONE, 2008 Ciguatoxins and brevetoxins are neurotoxic cyclic polyether compounds produced by dinoflagellates, which are responsible for ciguatera and neurotoxic shellfish poisoning (NSP) respectively. Recently, brevenal, a natural compound was found to specifically
César Mattei +9 more
doaj +1 more source
Marine Neurotoxins’ Effects on Environmental and Human Health: An OMICS Overview
Marine Drugs, 2021 Harmful algal blooms (HAB), and the consequent release of toxic metabolites, can be responsible for seafood poisoning outbreaks. Marine wildlife can accumulate these toxins throughout the food chain, which presents a threat to consumers’ health.
Sophie Guillotin, Nicolas Delcourt
doaj +1 more source