Results 51 to 60 of about 145 (130)

Stimulation of Neurite Outgrowth in Cerebrocortical Neurons by Sodium Channel Activator Brevetoxin-2 Requires Both N-Methyl-D-aspartate Receptor 2B (GluN2B) and p21 Protein (Cdc42/Rac)-Activated Kinase 1 (PAK1)

Marine Drugs, 2022
N-methyl-D-aspartate (NMDA) receptors play a critical role in activity-dependent dendritic arborization, spinogenesis, and synapse formation by stimulating calcium-dependent signaling pathways.
Suneet Mehrotra, Marsha L. Pierce, Shashank M. Dravid, Thomas F. Murray   +3 more
doaj   +1 more source

Die Chemie und Biologie der Tetrodotoxin Naturstofffamilie

Angewandte Chemie, Volume 137, Issue 35, August 25, 2025.
Tetrodotoxin ist vor allem als das Gift des Kugelfisches bekannt, einer Delikatesse in der japanischen Küche. Seine Toxizität beruht auf der selektiven Blockade von NaV Kanälen, wie am Beispiel der NaV1.7 Pore dargestellt, wobei das DEKA Motiv hervorgehoben ist, das für die Durchlässigkeit von Natriumionen verantwortlich ist.
Benedikt Nißl, Marcel Mülbaier, Francesca Grisoni, Dirk Trauner, Marcel Bermúdez, Clemens Dialer, David B. Konrad   +6 more
wiley   +1 more source

Development of a Rapid Throughput Assay for Identification of hNav1.7 Antagonist Using Unique Efficacious Sodium Channel Agonist, Antillatoxin

Marine Drugs, 2016
Voltage-gated sodium channels (VGSCs) are responsible for the generation of the action potential. Among nine classified VGSC subtypes (Nav1.1–Nav1.9), Nav1.7 is primarily expressed in the sensory neurons, contributing to the nociception transmission ...
Fang Zhao, Xichun Li, Liang Jin, Fan Zhang, Masayuki Inoue, Boyang Yu, Zhengyu Cao   +6 more
doaj   +1 more source

The Chemistry and Biology of the Tetrodotoxin Natural Product Family

Angewandte Chemie International Edition, Volume 64, Issue 35, August 25, 2025.
Tetrodotoxin is best known as the poison of the pufferfish, which is a delicacy in Japanese cuisine. Its toxicity arises from the selective blockage of NaV channels, which is depicted for the NaV1.7 pore, highlighting the DEKA motif, which permeates sodium ions.
Benedikt Nißl, Marcel Mülbaier, Francesca Grisoni, Dirk Trauner, Marcel Bermúdez, Clemens Dialer, David B. Konrad   +6 more
wiley   +1 more source

Effectors of thioredoxin reductase: Brevetoxins and manumycin-A

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2019
The activities of two effectors, brevetoxin (PbTx) and manumycin-A (Man-A), of thioredoxin reductase (TrxR) have been evaluated against a series of fourteen TrxR orthologs originating from mammals, insects and protists and several mutants. Man-A, a molecule with numerous electrophilic sites, forms a covalent adduct with most selenocystine (Sec ...
Anupama, Tuladhar, Robert J, Hondal, Ricardo, Colon, Elyssa L, Hernandez, Kathleen S, Rein   +4 more
openaire   +3 more sources

Metabolomics Approach to Reveal the Effects of Ocean Acidification on the Toxicity of Harmful Microalgae: A Review of the Literature

AppliedChem, 2023
Climate change has been associated with intensified harmful algal blooms (HABs). Some harmful microalgae produce toxins that accumulate in food webs, adversely affecting the environment, public health and economy.
Tsz-Ki Victoria Tsui, Hang-Kin Kong
doaj   +1 more source

Opinion of the French Agency for Food, Environmental and Occupational Health & Safety (ANSES) on the risks to human health associated with the proliferation of Ostreopsis spp. on the Basque coast

Food Risk Assess Europe, Volume 3, Issue 2, April 2025.
Abstract In France, the presence of marine microalgae of the genus Ostreopsis has been identified repeatedly on the Mediterranean coast for several years, whereas on the French Basque coasts its presence is much more recent. In the summers of 2021 and 2022, major Ostreopsis flowering episodes were reported on the Basque coast, resulting in several ...
Rodolphe Lemée, Jean‐François Humbert, Eric Abadie, Zouher Amzil, Elisa Berdalet, Ronel Biré, Marie‐Yasmine Dechraoui Bottein, Luc de Haro, Nicolas Delcourt, Valérie Fessard, Jean‐Philippe Jaeg, César Mattei, Anne Oppliger, Anne‐Sophie Pavaux, Eva Ternon, Gilles Bornert, Anne Togola, Jean Baron, Jean‐Luc Boudenne, Nicolas Cimetiere, Bruno Coulomb, Christophe Dagot, Sabine Denooz, Isabelle Dublineau, Frédéric Feder, Matthieu Fournier, Stéphane Garnaud‐Corbel, Nathalie Garrec, Johnny Gasperi, Julio Gonçalvès, Jean‐Louis Gonzalez, Olivier Horner, Michel Joyeux, Jérôme Labanowski, Sophie Lardy‐Fontan, Françoise Lucas, Christophe Mechouk, Laurent Moulin, Damien Mouly, Fabienne Petit, Catherine Quiblier, Pauline Rousseau‐Gueutin, Marie‐Pierre Sauvant‐Rochat, Michèle Tremblay, Bruno Le Bizec, Marie‐Louise Scippo, Pierre‐Marie Badot, Marie‐Yasmine Bottein, Rachida Chekri, Christine Demeilliers, Virginie Desvignes, Erwan Engel, Gautier Eppe, Anne‐Sophie Ficheux, Eric Houdeau, Emilie Lance, Olivier Laprevote, Michel Laurentie, Ludovic Le Hegarat, Jean‐Charles Leblanc, Nicolas Loiseau, David Makowski, Francesca Mancini, Eric Marchioni, Jean‐François Masfaraud, Mathilde Munier, Isabelle Oswald, Anne Platel, Yann Sivry, Paule Vasseur, Estelle Checlair‐Westerberg, Eléonore Ney, Nathalie Arnich, Carole Catastini   +73 more
wiley   +1 more source

Further Insights into Brevetoxin Metabolism by de Novo Radiolabeling

Toxins, 2014
The toxic dinoflagellate Karenia brevis, responsible for early harmful algal blooms in the Gulf of Mexico, produces many secondary metabolites, including potent neurotoxins called brevetoxins (PbTx).
Kevin Calabro, Jean-Marie Guigonis, Jean-Louis Teyssié, François Oberhänsli, Jean-Pierre Goudour, Michel Warnau, Marie-Yasmine Dechraoui Bottein, Olivier P. Thomas   +7 more
doaj   +1 more source

HABs Karenia brevis and Pseudo-nitzschia pre- and post-Hurricane Michael

Journal of Water and Health, 2023
Increased occurrences of harmful algal blooms (HAB) in the Gulf of Mexico, and even worldwide, yield concern for increases in brevetoxin exposure leading to respiratory illness or even death, highlighting the need for extensive scientific research and ...
Josh Alarcon, Lauren Ward, Ke Pan, Elaina Gonsoroski, Christopher K. Uejio, Leslie Beitsch, Maureen Y. Lichtveld, Emily W. Harville, Samendra Sherchan   +8 more
doaj   +1 more source

Impact of Hurricane Ian (2022) on Karenia brevis Bloom on the West Florida Shelf

Geophysical Research Letters, Volume 52, Issue 6, 28 March 2025.
Abstract Blooms of toxigenic Karenia brevis are a major concern to public health and marine ecosystems on the West Florida Shelf. Hurricanes and tropical storms can discharge huge amounts of terrestrial nutrients into coastal oceans over a short time and have been linked to large plankton blooms, but the underlying mechanisms for the bloom generation ...
Yuren Chen, Ming Li
wiley   +1 more source