Results 81 to 90 of about 145 (130)
Frontiers in ToxicologyAlthough adverse health effects from harmful algal bloom (HAB) toxins have been described since antiquity, the true worldwide incidence and disease burden has yet to be defined.
Brett Johnson +4 more
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The Cardioprotective Potential of Marine Venom and Toxins
ToxinsCardiovascular disease (CVD) continues to be the primary cause of morbidity and mortality worldwide, underscoring the urgent need for novel therapeutic alternatives.
Virginia Heaven Mariboto Siagian +1 more
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The structure and mode of action of the dinoflagellate toxins
Iranian South Medical Journal, 2016 Background: Dinoflagellates are the major causative agents of harmful algal blooms. In different studies, it has been shown that many dinoflagellate species produce various natural toxins.
Akram Najafi, Iraj Nabipour
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Neurotoxic Shellfish Poisoning
Marine Drugs, 2008 Neurotoxic shellfish poisoning (NSP) is caused by consumption of molluscan shellfish contaminated with brevetoxins primarily produced by the dinoflagellate, Karenia brevis. Blooms of K.
Roberta Hammond +3 more
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Total synthesis of brevetoxin A
Nature, 1998Brevetoxin A is the most potent neurotoxin secreted by Gymnodinium breve Davis, a marine organism often associated with harmful algal blooms known as 'red tides'. The compound, whose mechanism of action involves binding to and opening of sodium channels, is sufficiently toxic to kill fish at concentrations of nanograms per ml and, after accumulation in
K C, Nicolaou +5 more
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Antibodies to brevetoxin B: Serologic differentiation of brevetoxin B and brevetoxin A
Toxicon, 1992A brevetoxin B immunogen was prepared by reacting brevetoxin B with the amino groups of bovine albumin followed by treatment with sodium borohydride. Immunized rabbits produced antibodies that bound [3H]brevetoxin B-alcohol. This binding increased with repeated immunization (KD for one rabbit after three courses of immunization was about 10 pM ...
L, Levine, Y, Shimizu
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2000
Abstract Brevetoxins are lipid-soluble marine poisons synthesized by the red tide dinoflagellate Ptychodiscus brevis (previously Gymnodinium breve). These cyclic polyethers and structural relatives of ciguatoxin may induce massive killings of fish and also cause neurotoxic shell fish poisoning (NSP). NSP is a nonlethal intoxication of
Baden, Daniel G., Adams, David J.
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Abstract Brevetoxins are lipid-soluble marine poisons synthesized by the red tide dinoflagellate Ptychodiscus brevis (previously Gymnodinium breve). These cyclic polyethers and structural relatives of ciguatoxin may induce massive killings of fish and also cause neurotoxic shell fish poisoning (NSP). NSP is a nonlethal intoxication of
Baden, Daniel G., Adams, David J.
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Brevetoxin derivatives that inhibit toxin activity [PDF]
Chemistry and Biology, 2000 The brevetoxins are marine neurotoxins that interfere with the normal functions of the voltage-gated Na(+) channel. We have identified two brevetoxin derivatives that do not exhibit pharmacological properties typical of the brevetoxins and that function as brevetoxin antagonists.PbTx-3 and benzoyl-PbTx-3 elicited Na(+) channel openings during steady ...
Kathleen Rein +2 more
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Cardiovascular effects of brevetoxins in dogs
Toxicon, 1985In anesthetized spontaneously breathing dogs, brevetoxin caused dose-dependent periods of apnea and, at high doses, respiratory arrest. In artificially ventilated dogs, i.v. brevetoxin caused complex dose-related cardiovascular changes consisting of: (1) bradycardia; (2) triphasic blood pressure changes, sequentially characterized by depressor/pressor ...
G L, Johnson, J J, Spikes, S, Ellis
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