Results 161 to 170 of about 1,538 (200)

Absolute configuration of brevetoxins

Journal of the Chemical Society, Chemical Communications, 1986
The absolute configuration of the dinoflagellate toxins, brevetoxins, has been unequivocally determined by X-ray crystallography of a chiral dioxolane derivative.
Yuzuru Shimizu, Hideo Bando, Hong-Nong Chou, Gregory Van Duyne, Jon C. Clardy   +4 more
openaire   +1 more source

The structure of brevetoxin C

Tetrahedron Letters, 1982
Abstract The structure of brevetoxin C (BTX-C), a polyether marine toxin from Ptychodiscus brevis , has been elucidated by comparison of its spectral data with those of brevetoxin B (BTX-B).
Jerzy Golik, John C. James, Koji Nakanishi, Yong-Yeng Lin   +3 more
openaire   +1 more source

Identification of a Rapid Detoxification Mechanism for Brevetoxin in Rats [PDF]

Toxicological Sciences, 2005
We examined detoxification of brevetoxin in rats through metabolic activities and key elimination routes by analyzing samples from individual rats exposed to two brevetoxin congeners (PbTx-2 and PbTx-3). Brevetoxins were detected by radioimmunoassay in methanolic extracts of blood within 1 h post intraperitoneal (ip) administration.
John S Ramsdell
exaly   +3 more sources

Preservation of brevetoxins in Southwest Florida coastal sediments

Harmful Algae, 2022
Florida red tide is a natural phenomenon caused by the dinoflagellate, Karenia brevis. Karenia brevis blooms produce potent toxins (brevetoxins) that can cause neurotoxic and respiratory illness in humans and marine life. Red tides were recorded by Spanish explorers as early as the 17th century, however published red tide studies before 1940 are ...
James Javaruski, Puspa L. Adhikari, Joanne Muller, Michael L. Parsons   +3 more
openaire   +2 more sources

The chemistry of brevetoxins: A review

Toxicon, 1985
The structure of the unique 'red tide' dinoflagellate neurotoxin, brevetoxin-B is presented and the experimental data supporting the chemical structure is discussed. A brief account of the other brevetoxins and their structural relationships is also presented.
openaire   +2 more sources

Improved Synthesis of the ABCDE Fragment of Brevetoxin A

Organic Letters, 2006
A second-generation synthesis of the BCDE fragment of brevetoxin A is described. Novel reactions were developed that extend the utility of the asymmetric glycolate alkylation reaction and improve scale-up to provide gram quantities of the B and E subunits. Significant improvements to the convergent assembly of the tetracycle were also realized.
Michael T, Crimmins, Patrick J, McDougall, J Michael, Ellis   +2 more
openaire   +2 more sources

Distribution of Brevetoxin to Lipoproteins in human plasma

Toxicon, 2007
To better understand the distribution of brevetoxins in lipoproteins, including their role in tissue delivery and toxin elimination in humans, we examined the interaction of brevetoxin congener PbTx-3 with human lipoproteins. In a scintillation proximity assay (SPA) and microtiter equilibrium dialysis, brevetoxin bound linearly to purified human high ...
Ricky T, Woofter, John S, Ramsdell
openaire   +2 more sources

Immune effects of the neurotoxins ciguatoxins and brevetoxins

Toxicon, 2018
Ciguatoxins (CTXs) and brevetoxins (PbTxs) are phycotoxins that can accumulate along the marine food chain and thus cause seafood poisoning in humans, namely "ciguatera fish poisoning" (CFP) and "neurotoxic shellfish poisoning" (NSP), respectively. CFP is characterized by early gastrointestinal symptoms and typical sensory disorders (paraesthesia, pain,
Ophelie Pierre, Laurent Misery, Matthieu Talagas, Raphaele Le Garrec   +3 more
openaire   +2 more sources

Brevetoxins: Toxicological Profile

2015
Brevetoxins (PbTxs) are polyether ladder-shaped neurotoxins produced by the dinoflagellate Karenia brevis. Blooms of K. brevis have been recorded since the mid-1800s, principally in the Gulf of Mexico but occasionally along the mid and south Atlantic coasts.
BROVEDANI, VALENTINA, PELIN, MARCO, D'ORLANDO, ELISABETTA, Poli, Mark   +3 more
openaire   +2 more sources

Brevetoxins: unique polyether dinoflagellate toxins

The FASEB Journal, 1989
Brevetoxins are lipid‐soluble polyether marine toxins of unique structure and pharmacological function. Toxins are active in vivo in the nanomolar to picomolar concentration range and in vitro in isolated neuromuscular or giant axon preparations and in single‐cell or subcellular model systems.
openaire   +2 more sources