Results 121 to 130 of about 733 (153)

Improved Synthesis of the ABCDE Fragment of Brevetoxin A

Organic Letters, 2006
A second-generation synthesis of the BCDE fragment of brevetoxin A is described. Novel reactions were developed that extend the utility of the asymmetric glycolate alkylation reaction and improve scale-up to provide gram quantities of the B and E subunits. Significant improvements to the convergent assembly of the tetracycle were also realized.
Michael T, Crimmins, Patrick J, McDougall, J Michael, Ellis   +2 more
openaire   +2 more sources

Aerosolized Red-Tide Toxins (Brevetoxins) and Asthma [PDF]

Chest, 2007
With the increasing incidence of asthma, there is increasing concern over environmental exposures that may trigger asthma exacerbations. Blooms of the marine microalgae, Karenia brevis, cause red tides (or harmful algal blooms) annually throughout the Gulf of Mexico.
, Yung Sung Cheng
exaly   +3 more sources

Distribution of Brevetoxin to Lipoproteins in human plasma

Toxicon, 2007
To better understand the distribution of brevetoxins in lipoproteins, including their role in tissue delivery and toxin elimination in humans, we examined the interaction of brevetoxin congener PbTx-3 with human lipoproteins. In a scintillation proximity assay (SPA) and microtiter equilibrium dialysis, brevetoxin bound linearly to purified human high ...
Ricky T, Woofter, John S, Ramsdell
openaire   +2 more sources

Immune effects of the neurotoxins ciguatoxins and brevetoxins

Toxicon, 2018
Ciguatoxins (CTXs) and brevetoxins (PbTxs) are phycotoxins that can accumulate along the marine food chain and thus cause seafood poisoning in humans, namely "ciguatera fish poisoning" (CFP) and "neurotoxic shellfish poisoning" (NSP), respectively. CFP is characterized by early gastrointestinal symptoms and typical sensory disorders (paraesthesia, pain,
Ophelie Pierre, Laurent Misery, Matthieu Talagas, Raphaele Le Garrec   +3 more
openaire   +2 more sources

A Highly Convergent Approach to Brevetoxin A

Organic Letters, 2007
Through optimized, scaled-up routes to the G and J rings of brevetoxin A, a convergent strategy based upon a Horner-Wadsworth-Emmons coupling reaction completed the GHIJ fragment. Further studies toward an alternative protecting group strategy for the GHIJ fragment elucidated a shortened synthesis.
Michael T, Crimmins, J Lucas, Zuccarello, Pamela A, Cleary, Jonathan D, Parrish   +3 more
openaire   +3 more sources

Brevetoxins: unique polyether dinoflagellate toxins

The FASEB Journal, 1989
Brevetoxins are lipid‐soluble polyether marine toxins of unique structure and pharmacological function. Toxins are active in vivo in the nanomolar to picomolar concentration range and in vitro in isolated neuromuscular or giant axon preparations and in single‐cell or subcellular model systems.
openaire   +2 more sources

Brevetoxins: Toxicological Profile

2015
Brevetoxins (PbTxs) are polyether ladder-shaped neurotoxins produced by the dinoflagellate Karenia brevis. Blooms of K. brevis have been recorded since the mid-1800s, principally in the Gulf of Mexico but occasionally along the mid and south Atlantic coasts.
BROVEDANI, VALENTINA, PELIN, MARCO, D'ORLANDO, ELISABETTA, Poli, Mark   +3 more
exaly   +3 more sources

Distribution and elimination of brevetoxin PbTx-3 in rats

Toxicon, 1990
After i.v. administration, [3H]PbTx-3 was rapidly cleared from the blood; less than 10% remained after 1 min. Within 30 min, radiolabel distributed to skeletal muscle (69.5%), liver (18.0%), and intestinal tract (8.0%). Over 24 hr, radiolabel decreased in muscle, remained constant in liver, and increased in the intestinal tract and feces.
M A, Poli, C B, Templeton, W L, Thompson, J F, Hewetson   +3 more
openaire   +2 more sources

Brevetoxin binding: molecular pharmacology versus immunoassay

Toxicon, 1988
Brevetoxin PbTx-3 isolated from Florida's red tide dinoflagellate Ptychodiscus brevis has been produced recently in tritiated form by reductive tritiation of brevetoxin PbTx-2. Tritiated PbTx-3 has been used as a specific probe in competitive radioimmunoassays developed to detect brevetoxins in food sources, and this probe has also been utilized to ...
D G, Baden, T J, Mende, A M, Szmant, V L, Trainer, R A, Edwards, L E, Roszell   +5 more
openaire   +2 more sources

Brevetoxins

Brevetoxins (BTXs) are potent marine toxins produced by certain microalgae during harmful algal blooms (HABs). These lipophilic polyether compounds, notably PbTx-1 and PbTx-2, primarily affect seafood safety by bioaccumulating in filter-feeding shellfish and finfish.
openaire   +1 more source