Topical application of marine briarane-type diterpenes effectively inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and dermatitis in murine skin [PDF]
Journal of Biomedical Science, 2011 Background Skin is the largest organ in the body, and is directly exposed to extrinsic assaults. As such, the skin plays a central role in host defense and the cutaneous immune system is able to elicit specific local inflammatory and systemic immune ...
Wei Wen-Chi +7 more
doaj +7 more sources
Chemical and Pharmaceutical Bulletin, 2008 Four new briarane-related diterpenoids, designated as briaexcavatins M-P (1-4), were isolated from the cultured octocoral Briareum excavatum. The structures, including the relative configurations of natural products 1-4 were established on the basis of extensive spectral data analysis and by comparison with the spectral data from other known ...
Ping‐Jyun Sung +7 more
semanticscholar +6 more sources
Excavatoids L-N, New 12-Hydroxybriaranes from the Cultured Octocoral Briareum excavatum (Briareidae)
Chemical and Pharmaceutical Bulletin, 2010 Three new 12-hydroxybriarane diterpenoids, excavatoids L-N (1-3), have been isolated from the cultured octocoral Briareum excavatum. The structures of new briaranes 1-3 were elucidated by the interpretations of spectroscopic methods. Excavatoid L (1) displayed moderate inhibitory effects on superoxide anion generation and elastase release by human ...
Jui‐Hsin Su +11 more
semanticscholar +6 more sources
Research Progress on Natural Diterpenoids in Reversing Multidrug Resistance. [PDF]
Front Pharmacol, 2022 Multidrug resistance (MDR) is one of the main impediments in successful chemotherapy in cancer treatment. Overexpression of ATP-binding cassette (ABC) transporter proteins is one of the most important mechanisms of MDR. Natural products have their unique
Deng ZF +6 more
europepmc +3 more sources
Stereoselective Synthesis of Quaternary Carbons via the Dianionic Ireland-Claisen Rearrangement: An Approach to the Synthesis of Briarane Diterpenes [PDF]
Tetrahedron, 2012 Investigation of the dianionic Ireland-Claisen rearrangement has led to the development of a simple method to enantioselectively access quaternary carbon stereocenters via a chelated transition state.
Williams, Philip S.
core +3 more sources
Total synthesis of (-)-mucocin and studies toward the asymmetric total synthesis of brianthein A [PDF]
ChemInform, 2007 A highly convergent asymmetric total synthesis of antitumor acetogenin natural product (-)-mucocin is described. This approach combined asymmetric glycolate aldol additions with ring-closing metatheses to construct cyclic ethers.
Zhang, Yan
core +3 more sources
The application and sustainable development of coral in traditional medicine and its chemical composition, pharmacology, toxicology, and clinical research. [PDF]
Front Pharmacol, 2023 This review discusses the variety, chemical composition, pharmacological effects, toxicology, and clinical research of corals used in traditional medicine in the past two decades.
Han M, Wang Z, Li Y, Song Y, Wang Z.
europepmc +3 more sources
Tetrahydrofuran cembranoids from the cultured soft coral Lobophytum crassum. [PDF]
Mar Drugs, 2011 Three new cembranoids, culobophylins A–C (1–3), along with two known compounds (4 and 5) were isolated from the cultured soft coral Lobophytum crassum.
Lee NL, Su JH.
europepmc +4 more sources
Oceanic Breakthroughs: Marine-Derived Innovations in Vaccination, Therapy, and Immune Health. [PDF]
Vaccines (Basel)The vast, untapped potential of the world’s oceans is revealing groundbreaking advancements in human health and vaccination. Microalgae such as Nannochloropsis spp.
Gamberi C +10 more
europepmc +3 more sources