Results 111 to 120 of about 2,121,605 (282)

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

The relationship between academic stress and depressive symptoms in middle school students: a network analysis model

BMC Psychology
Objective Based on network analysis methodology, a network model was constructed to elucidate the relationship between academic stress and depressive symptoms among middle school students.
Ke Zheng, Zijun Chen, Liang Yu
doaj   +1 more source

Bridge Engineering Section, March 2014

, 2014
This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF caption (viewed on April 11, 2014)"Updated ...

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Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Association between interpersonal sensitivity and loneliness in college nursing students based on a network approach

BMC Nursing
Background The symptoms of interpersonal sensitivity and loneliness are prevalent among college nursing students. This study aims to investigate the interactions at the symptom level and elucidate the characteristics of the interpersonal sensitivity and ...
Jiukai Zhao, Yibo Wu, Jie Yuan, Juanxia Miao, Xue Wang, Yu Yang, Shuang Zang   +6 more
doaj   +1 more source

Bridge naming rules

, 2000
This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes."Bridge operations R.L.

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Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Clermont County Covered Bridge

Photograph identified as covered bridge #359 in Clermont County, Ohio, date ...
Ohio Covered Bridge Association
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Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Network analysis of neuropsychiatric symptoms in mild behavioral impairment among nursing homes: an observational study

BMC Geriatrics
Background Mild behavioral impairment (MBI) is considered a high-risk factor for dementia, characterized by emergent and sustained neuropsychiatric symptoms (NPS). This study examined the complex co-occurring symptoms and symptom clusters of NPS in older
Bingjie Wei, Yuanjiao Yan, Yanhong Shi, Rong Lin, Chenshan Huang, Xiaozhen Fu, Hong Li   +6 more
doaj   +1 more source