Results 131 to 140 of about 2,121,605 (282)

The interplay among burnout, and symptoms of depression, anxiety, and stress in Chinese clinical therapists

open access: yesScientific Reports
Burnout, depression, anxiety, and stress negatively impact the well-being and retention of healthcare professionals. The interplay of these symptoms is understudied.
Mengyue Gu   +14 more
doaj   +1 more source

Laboratory and Field Testing of an Accelerated Bridge Construction Demonstration Bridge: US Highway 6 Bridge over Keg Creek, RB02-012, 2013 [PDF]

open access: yes, 2013
The US Highway 6 Bridge over Keg Creek outside of Council Bluffs, Iowa is a demonstration bridge site chosen to put into practice newly-developed Accelerated Bridge Construction (ABC) concepts.

core  

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

open access: yesAdvanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie   +12 more
wiley   +1 more source

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

open access: yesAdvanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu   +12 more
wiley   +1 more source

Network analysis of mental health literacy and depressive/anxiety symptoms in patients under maintenance hemodialysis: a cross-sectional study of multicenter data

open access: yesScientific Reports
To explore the network structures and gender differences of mental health literacy (MHL) and depressive/anxiety symptoms in maintenance hemodialysis (MHD) patients and identify core symptoms and bridge symptoms.
Guifang Xue   +7 more
doaj   +1 more source

Hypomethylation of GNA15 Promotes Pancreatic Ductal Adenocarcinoma Progression and Macrophage M2 Polarization via STAT3‐CXCL8 Axis

open access: yesAdvanced Science, EarlyView.
A schematic model summarizing GNA15's mechanism in mediating macrophage M2 polarization and Gemcitabine resistance. ABSTRACT The complexity of pancreatic ductal adenocarcinoma (PDAC) progression, coupled with the lack of effective immunotherapy, underscores the imperative to deepen our understanding of its mechanisms and identify suitable immune ...
Weihui Guo   +8 more
wiley   +1 more source

A network analysis of the depression and anxiety comorbidity: a nationwide survey among Chinese adolescents during the normalization phase of COVID-19 pandemic prevention and control

open access: yesBMC Psychiatry
Objectives This study employed network analysis to investigate the comorbidity model between depression and anxiety among Chinese adolescents during the normalization phase of COVID-19 pandemic prevention and control.
Tingting Li   +8 more
doaj   +1 more source

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