Results 121 to 130 of about 2,121,605 (282)

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

Bridge symptoms between parenting styles and proximal psychological risk factors associated with adolescent suicidal thoughts: a network analysis. [PDF]

Child Adolesc Psychiatry Ment Health, 2023
Ou W, Yang Y, Chen Y, Li Y, Yang S, Lu Y, Li L, Huang M, Ma M, Lv G, Zhao X, Qing Y, Ju Y, Zhang Y.   +13 more
europepmc   +1 more source

Traffic data collection using a bridge-weigh-in-motion system in a cable-stayed bridge

, 2017
Reliable live traffic data collection is crucial for effective pavement life prediction, fatigue estimation, vibration control, maintenance, and condition assessment of the bridge structures.
Samali, Bijan (R17646), Kalhor, Hamed, Zhu, Xinqun (R14089), Alamdari, Mehrisadat M.   +3 more
core  

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Network analysis of depression, anxiety, and NSSI symptoms in adolescents: a clinical sample study

BMC Psychiatry
Objective This study aimed to construct a symptom network model of depression, anxiety, and NSSI using network analysis and to identify the most central and bridge symptoms within the depression-anxiety-NSSI symptom network.
Xiaoyu Jiang, Zhikun Zhang, Ziyi Wei, Guangde Shi, Miaoyu Yu, Junduan Wu   +5 more
doaj   +1 more source

Rainbow Bridge

, 2001
On the morning of August 14, 1909, a small, diverse group including Professor Byron Cummings of the University of Utah, Government Land Office surveyor William Douglass, pioneer archaeologist and trader John Weatherill, and Paiute guide Nasja Begay gazed
Hassell, Hank., Hank Hassell
core   +1 more source

In Situ Profiling of Nanoscale Strains Uncovers Mechano‐Architectural Predictors of Aging and Osteoarthritis Emergence

Advanced Science, EarlyView.
In situ mechanical loading of osteoarthritis‐prone murine knee joints reveals that spatial alterations in subchondral plate microarchitecture precede cartilage loss and promote a shift from coordinated epiphyseal strain dissipation in healthy joints to focal subchondral strain concentration in osteoarthritis‐prone joints.
Aikta Sharma, Lucinda A. E. Evans, Lucie E. Bourne, Jishizhan Chen, Alissa L. Parmenter, Joseph Brunet, Kamel Madi, Sebastian Marussi, Andrew A. Pitsillides, Peter D. Lee, Katherine A. Staines   +10 more
wiley   +1 more source

A network analysis of postpartum depression and mother-to-infant bonding shows common and unique symptom-level connections across three postpartum periods

Communications Psychology
Postpartum depression and mother-to-infant bonding difficulties (MIBD), two issues crucial to maternal and infant mental health, often coexist and affect each other.
Norihiro Harasawa, Chong Chen, Sumiyo Okawa, Ryo Okubo, Toshio Matsubara, Shin Nakagawa, Takahiro Tabuchi   +6 more
doaj   +1 more source

The proposed Australasian composite bridge standard, AS/NZS 5100 Part 6, Steel and composite construction

, 2013
This paper details the ongoing progress by the Australian Standards Committee BD-90-06 on the Australasian Standard for Bridge Design, Steel and Composite Construction, AS/NZS 5 100 Part 6 which is currently being prepared for public comment and is ...
Uy, Brian, Kang, Won-Hee (R16823), Hicks, Stephen   +2 more
core  

Ultrasound‐Activated Piezoelectric Neuroimmune Hydrogel Orchestrates Neurogenesis‐Macrophage Crosstalk in Diabetic Wound Healing

Advanced Science, EarlyView.
In this work, we design an ultrasound‐activated piezoelectric hydrogel platform (AOEF@AP5+US) that reprograms neurogenesis‐macrophage crosstalk as an integrated strategy to overcome the intertwined barriers of chronic inflammation, peripheral neuropathy, and impaired regeneration in diabetic wounds.
Kai Wang, Shaowen Zhuo, Binyu Song, Jinan Chen, Xin Zhao, Sijia Li, Shuang You, Dong Jiang, Yuedong Chen, Juanli Dang, Tong Wang, Baolin Guo, Zhou Yu, Baoqiang Song   +13 more
wiley   +1 more source