Results 1 to 10 of about 4,585 (84)

Catalytic asymmetric tandem Heck/Sonogashira reaction enabling access to versatile chiral bridged ring scaffolds [PDF]

Nature Communications
Bridged-ring scaffolds are prevalent in numerous natural products and pharmaceuticals. However, achieving enantioselective construction of these architectures presents a significant challenge, due to the considerable structural strain of the products and
Jing Zhong, Mengxian Li, Changhui Wu, Hui Li, Hongyue Dong, Chunchen Che, Aijun Lin, Hequan Yao   +7 more
doaj   +2 more sources

Enantioselective Synthesis of 2-Oxabicyclo[2.1.1]hexanes and Bicyclo[2.1.1]hexanes via Catalytic Asymmetric Intramolecular Photocycloadditions [PDF]

Nature Communications
Due to the ubiquitous presence of ortho-disubstituted benzenes in pharmaceuticals and agrochemicals, the exploration of their bioisosteres incorporating three-dimensional bridged cyclic scaffolds has attracted significant interest among chemists in ...
Dong Tian, Chaofan Qu, Shanshan Cao, Bin Yu, Xiaowei Zhao, Junmin Zhang, Zhiyong Jiang   +6 more
doaj   +2 more sources

Switchable organocatalytic enantioselective sulfenocyclization of cyclohexadienes enabling chemodivergent access to chiral bicyclo[m.n.1] ring systems [PDF]

Nature Communications
The precise control over regio- and stereoselectivity from the same substrate represents a significant challenge in organic chemistry. Herein, a switchable organocatalytic enantioselective carbosulfenylation/sulfenolactonization of cyclohexa-1,4-dienes ...
Bing-Qian Zhang, Lei Chen, Wen-Ying Xiao, Yidong Liu, Yin-Long Li, Jun Deng   +5 more
doaj   +2 more sources

Acid-Catalyzed Hydrolysis of Bridged Bi- and Tricyclic Compounds. XXIX. 7-Oxa-5-oxo-2-bicyclo[2.2.1]heptene: Kinetics and Mechanism. [PDF]

Acta Chemica Scandinavica, 1991
7-Oxa-5-oxo-bicyclo [2.2.1] heptene (7-oxanorborn-2-en-5-one) produces in concentrated (5-8.5 mol dm −3 ) aqueous perchloric acid mainly 1,2-dihydroxybenzene. The reaction is initiated by the pre-equilibrium protonation of the ether oxygen atom and the subsequent rupture of the C(1)-O(7) bond.
Martti Lajunen, Esa Mäki, Arne Holm, Niels Harrit, Lars I. Elding, I. Trabjerg   +5 more
openaire   +1 more source

One-pot Diels–Alder cycloaddition/gold(I)-catalyzed 6-endo-dig cyclization for the synthesis of the complex bicyclo[3.3.1]alkenone framework

Beilstein Journal of Organic Chemistry, 2011
The rapid synthesis of bicyclo[m.n.1]alkanone cores possessing quaternary carbon centers adjacent to a bridged ketone represents a significant synthetic challenge.
Boubacar Sow, Gabriel Bellavance, Francis Barabé, Louis Barriault   +3 more
doaj   +1 more source

Catalytic Cyclocodimerization of Silicon-Containing 1,2-Dienes with 1,3,5-Cycloheptatriene in the Synthesis of Biologically Active Bicyclo[4.2.1]Nona-2,4-Dienes

Chemistry Proceedings
The [6+2] cycloaddition of (2-butyl-2,3-butadienyl)(trimethyl)silane and 2,3-butadienyl(trimethyl)silane to 1,3,5-cycloheptatriene was studied using titanium- and cobalt-containing multicomponent catalytic systems: R2TiCl2-R’nAlCl3-n (R = acac, PriO ...
Gulnara N. Kadikova
doaj   +1 more source

Cyclopropanation of unactivated alkenes with diazo compounds enables facile synthesis of challenging cyclopropanes and late-stage sesquiterpene modification. [PDF]

Chem Sci
Zhang L, Zhang N, Wang D, Yuan X, Han X, Zhuo M, Guo G, Zhang WD, Zhang H, Zhang Y.   +9 more
europepmc   +1 more source

Breaking the 'rule-of-five' to access bridged bicyclic heteroaromatic bioisosteres. [PDF]

Nat Synth
Zhang ZX, Shu K, Tilby MJ, Mandigma MJP, Guo Y, Tyler JL, Noble A, Aggarwal VK.   +7 more
europepmc   +1 more source

Photocatalytic Stereoselective Editing of Alkynes to 3D Molecules via Hydrogen Atom Transfer-Mediated Dynamic Epimerization. [PDF]

Nat Commun
Gu Z, Zeng T, Yuan Z, Zheng H, Zhu G.
europepmc   +1 more source

Formal Diels-Alder reaction of saturated carboxylic acids via C-H activation. [PDF]

Nat Chem
He Q, Lu Y, Sheng T, Chekshin N, Yan JL, Zhang T, Yu JQ.   +6 more
europepmc   +1 more source