Bridged Bicyclic Compounds [PDF]
, 1973 This thesis is concerned with certain aspects of the application of Bredt's Rule in bridged bicyclic compounds. The reported monodecarboxylation of bicyclo[2,2,2]-octane-2,5-dione-1,4-dicarboxylic acid (1) to give bicyclo-[2,2,2]octane-2,5-dione-l ...
Kean, Norman Buchanan
core +6 more sources
Cobalt/Photoredox Catalyzed Desymmetrization of Oxo and Azabicycles via Asymmetric Reductive Coupling With Alkynes. [PDF]
Adv Sci (Weinh)A one‐step, asymmetric reductive coupling of alkynes and oxa‐ and aza‐bicyclic olefins using a cobalt/photoredox catalytic system through desymmetrization. ABSTRACT Bicyclo[2.2.1]heptane frameworks represent a privileged structural motif prevalent in numerous natural products and bioactive molecules.
Pradhan S +5 more
europepmc +2 more sources
Bridged Bicyclic Compounds [PDF]
, 1970 This thesis is concerned with the synthesis, spectral properties and reactivities of bicyclo(5.3.1.)undec-7ene-11-one and bicyclo(5.3.1.)undec-7(11)-ene-8-one in each of which the double bond is at the bridgehead, in defiance of Bredt's rule.
Jamieson, George
core +6 more sources
Bridged Bicyclic Building Block Upgrading: Photochemical Synthesis of bicyclo[3.1.1]heptan-1-Amines [PDF]
, 2020 Compounds containing bridged bicyclic carbon skeletons are desirable building blocks for medicinal chemistry. However, as a result of their inefficient, linear syntheses, commercially available compounds of this sort are plagued by high costs and/or a ...
Alexander, Harmata +2 more
core +1 more source
Bicyclo[m.n.k]alkane Building Blocks as Promising Benzene and Cycloalkane Isosteres: Multigram Synthesis, Physicochemical and Structural Characterization [PDF]
, 2023 Electrophilic double bond functionalization – intramolecular enolate alkylation sequence was used to obtain a series of bridged and fused bicyclo[m.n.k]alkane derivatives (i.e., bicyclo[4.1.1]octanes, bicyclo[2.2.1]heptanes, bicyclo[3.2.1]octanes ...
Ihor, Fesun +9 more
core +1 more source
Synthesis of Bicyclo[1.1.0]butanes from Iodo-Bicyclo[1.1.1]pentanes [PDF]
, 2023 We describe a two step process for the synthesis of substituted bicyclo[1.1.0]butanes. A photo-Hunsdiecker reaction generates iodo-bicyclo[1.1.1]pentanes under metal-free conditions at room temperature.
Anthony, Paiva +13 more
core +2 more sources
New Nucleic Base-tethered Trithiolato-bridged Dinuclear Ruthenium(II)-Arene Compounds: Synthesis and Antiparasitic Activity [PDF]
, 2022 Aiming to generate novel compounds with improved antitoxoplama activity by exploiting the parasite auxotrophies, a library of nucleic base-tethered trithiolato-bridged dinuclear ruthenium(II)-arene conjugates - was synthesized and evaluated.
Emila, Păunescu +7 more
core +1 more source
Ring expansion of bicyclo[1.1.0]butyl ketones to bicyclo[2.1.1]hexenes using ketone as both activating and reacting groups. [PDF]
Nat CommunBicyclo[n.1.1]alkyl skeletons are of significant interest as bioisosteres of phenyl groups for lead drug modification. Common strategies for their synthesis utilize bicyclo[1.1.0]butanes, wherein the electron-withdrawing groups serve solely as activating
Ge J +8 more
europepmc +2 more sources
Skeletal Editing Approach to Bridge-Functionalized Bicyclo[1.1.1]pentanes from Aza-Bicyclo[2.1.1]hexanes [PDF]
, 2023 The ability to rapidly navigate a wide diversity of chemical space from simple building blocks is a cornerstone of medicinal chemistry campaigns. Aza-bicyclo[2.1.1]hexane (aza-BCH) and bicyclo[1.1.1]pentane (BCP) scaffolds have recently emerged as ...
Richmond, Sarpong +8 more
core +2 more sources
Angewandte Chemie, EarlyView.A metal‐free photocatalytic platform converts nitrones into 4‐isoxazolines and oxa–aza–bicycloheptanes through divergent [3+2π/σ] cycloadditions. Assembly‐controlled kinetic electron transfer gating dictates substrate activation, enabling selective reactivity beyond thermodynamic expectations.
Nayan Saha +6 more
wiley +2 more sources