Results 121 to 130 of about 507,526 (293)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

The Effect of Corrosion of Prestressing Reinforcement on the Behaviour of Concrete Bridges

open access: yesCivil and Environmental Engineering
Prestressed bridges have been a key element of transportation infrastructure for decades. Despite an expected service life of around 100 years under optimal design and maintenance, many structures exhibit damage that compromises their integrity or leads ...
Haššová Zuzana   +2 more
doaj   +1 more source

Use of Railroad Flat Cars for Low-Volume Road Bridges; TR-421, August 1999 [PDF]

open access: yes, 1999
In an attempt to solve the bridge problem faced by many county engineers, this investigation focused on a low cost bridge alternative that consists of using railroad flatcars (RRFC) as the bridge superstructure. The intent of this study was to determine

core  

Notice of meetings for Lavender Bridges and lesbian/gay rap group

open access: yes, 2021
These two meeting notices appear in the Classifieds section of the October 30 and November 6, 1986 issues of the Western Carolinian. One states Lavender Bridges will hold a regular meeting on Nov 6 for lesbians and gays only and the other meeting notice ...
Lavender Bridges;
core  

The Bridge [PDF]

open access: yesAmerican Journal of Kidney Diseases, 2021
openaire   +2 more sources

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

Dynamic Response of a Guardrail System Based on Prestressed Cables

open access: yesRomanian Journal of Transport Infrastructure
Road safety is a major global concern nowadays. Within the road infrastructure, bridge sectors are the most dangerous in terms of the incidence and severity of accidents.
Daniel Urdăreanu Vlad   +3 more
doaj   +1 more source

Condition assessment and strengthening of shear connection systems for composite bridges

open access: yes, 2011
Some old bridges in Australia were constructed with a deck system consisting of non-composite concrete slab over steel girders. The paper herein presents the methodology for structural retrofitting/ strengthening of these existing bridges based on their ...
Mirza, Olivia (R13978)   +2 more
core  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

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