Results 111 to 120 of about 507,526 (293)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
, 2018 Purpose: For atrial fibrillation (AF) patients receiving vitamin K antagonists (VKAs), careful management of anticoagulation is important around surgical procedures to minimize the stroke and bleeding risks. If the VKA needs to be stopped periprocedurally to reduce the risk of bleeding, a decision needs to be made whether to bridge this period with a ...
van der Pol, Simon +6 more
openaire +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Optimum design of composite prestressed concrete girder railway bridges [PDF]
, 2012 This paper deals with the formulation of design optimisation of pretsressed concrete bridges. The bridge is of a slab-on-girder type, hence modeled as an equivalent orthotropic plate.
Mohammed, S, Mohammad, F, Al-Nuaimi, A
core
Caissons for bridges over water [PDF]
, 2021 The design of foundations for over-water bridges and offshore marine terminals might be a challenging task for the bridge engineer. Whereas the ground conditions at the bridge location may be the dominating factor in the design of foundations for a ...
Guanchez Reyes, Edinson Asdrubal
core
Translational Psychiatry, 2011 With over 5000 journals indexed in PubMed, the announcement of a new journal generally elicits a raised brow along with some variation on these questions: Do we need another journal? Who can read even 10% of the journals covering neuropsychiatric science, either basic or clinical? Will more journals just permit more publishing of mediocre science?
openaire +2 more sources
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
The Influence of Correclation on the Extreme Traffic Loading of Bridges [PDF]
, 2012 Bridge Maintenance, Safety and Management (IABMAS'10) the Fifth International IABMAS Conference, Philadelphia, USA, 11-15 July 2010Accurate traffic loading models based on measured data are essential for the accurate assessment of existing bridges ...
O'Brien, Eugene J. +2 more
core +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source