Results 111 to 120 of about 406,893 (318)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Theoretical and Experimental Analysis of Stability Limits of Non-Axisymmetric Liquid Bridges under Microgravity Conditions [PDF]

, 1995
The stability of nonaxisymmetric liquid bridges under microgravity conditions is investigated. The influence on the stability of an almost cylindrical liquid bridge of axisymmetric effects like its volume, a small axial acceleration acting on it, and ...
Meseguer Ruiz, José, Rodríguez de Francisco, Pablo, Perales Perales, José Manuel, Bezdenejnykh, N.A.   +3 more
core   +1 more source

Bridges for Inclusion [PDF]

Forum Sociológico, 2010
O projecto Bridges for Inclusion tinha como principal objectivo identificar como é que poderia ser estabelecida uma mais efectiva relação entre as estratégias de emprego, protecção social e inclusão social, com base em experiências locais, de forma a evidenciar diferentes orientações e práticas.
openaire   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

ASSESSING WITH WEB-BASED TECHNOLOGIES THE SPACE SIGHT CAPABILITY OF THE STUDENTS

Journal of Industrial Design and Engineering Graphics, 2017
Mental Cutting Test (MCT) is a multiple-choice test consisting in mentally cutting 26 solids. For every problem, five answers were provided and learners had to identify the only one correct answer and to mark it. This paper presents the implementation of
NERISANU Raluca, VASILACHE Cosmin, DRAGAN Delia   +2 more
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Comparative Aspects Regarding the Behavior of Fiberglass and Steel Reinforcement in Bridge Beams

Romanian Journal of Transport Infrastructure
This study investigates the feasibility of employing fiberglass reinforcement as a substitute for conventional steel reinforcement in concrete bridge beams, with particular attention to mechanical performance and chemical stability within the alkaline ...
Marin Amăreanu, Ionuț-Radu Răcănel, Octavian Mazilu Claudiu, Constantin-Dorinel Voinițchi, George-Mădălin Pirontea   +4 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Use of Railroad Flat Cars for Low-Volume Road Bridges; TR-421, August 1999 [PDF]

, 1999
In an attempt to solve the bridge problem faced by many county engineers, this investigation focused on a low cost bridge alternative that consists of using railroad flatcars (RRFC) as the bridge superstructure. The intent of this study was to determine

core