Results 91 to 100 of about 507,526 (293)

A Parallel between Brownian Bridges and Gamma Bridges

open access: yesPublications of the Research Institute for Mathematical Sciences, 2004
Some properties of the Gamma bridges (obtained by conditioning the Gamma subordinator to take a given value at a given time) are investigated; similarities with the Brownian bridges are emphasized.
Yor, Marc, Emery, M.
openaire   +4 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Analysis of Behaviour of Steel Sleepers on a Railway Bridge with Member Deck

open access: yesCivil and Environmental Engineering
The article presents the results of experimental and numerical analyses of the behaviour of steel bridge sleepers on the steel railway bridge with member deck at km 5.230 of the A2 track in the Žilina – Teplička, marshalling yard section.
Gocál Jozef   +4 more
doaj   +1 more source

Asphalt Mixtures with Limestone Aggregate for Base Layer

open access: yesRomanian Journal of Transport Infrastructure, 2012
Mélanges asphaltiques sont des mélanges de granulats minéraux, de charge, du bitume et éventuellement des additifs, dans certaines proportions déterminées par la recette conçue au laboratoire.
Răcănel Carmen   +3 more
doaj   +1 more source

Fatigue Resistance of Typical Fatigue Prone Riveted Steel Railway Bridge Structural Detail

open access: yesCommunications, 2011
There are still a lot of riveted steel railway bridges built in the first half of 20th century in service, and so it is important to pay attention to their evaluation.
Josef Vican, Jozef Gocal, Jozef Jost
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Fatigue Assessment of Existing Bridge Members

open access: yesCommunications, 2007
Correct consideration of the service load effects plays a very important role on assessment of railway bridges, especially on fatigue assessment. Eurocode EN 1991-2 introduces twelve types of service trains and prescribes their sequel in normal and heavy
Josef Vican   +2 more
doaj   +1 more source

Letter to the editor by Co-Chair of Lavender Bridges

open access: yes, 2021
This January 30, 1986 letter to the editor signed Co-Chair, Lavender Bridges addresses the front-page article in the Western Carolinian from January 23 titled “Addressing gay concerns: Lavender Bridges recognized.” The author was misquoted in the article
Anonymous; Lavender Bridges;
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Bridges family Civil War letters

open access: yes
This collection contains four letters written by members of the families of Ira Bridges and his brother John, of Clark County, Ark., while they were serving in Arkansas units of the Confederate ...
Bridges, Charles T., 1836-1863
core   +1 more source

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