Results 91 to 100 of about 1,691,933 (287)
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Analysis of Out-Of-Plane Stability of Bow-String Arches
Communications, 2016 Several arch bridge superstructures, designed by the authors of the paper, are presented and analysed. Spatial FEM models were utilised to analyse behaviour of each bridge.
Josef Vican +2 more
doaj +1 more source
Nominal GDP Targeting: A Policy Recommendation to Meet the Fed’s Dual Mandate
, 2015 This paper was written in early December 2014 in response to the Federal Reserve Challenge Team’s argument for a regime change in the Federal Reserve to nominal GDP targeting as the appropriate policy to return the U.S.
Bridges, R. Shaw
core
Transportation and Taxes: What New Hampshire Residents Think About Maintaining Highways and Bridges [PDF]
, 2017 In this brief, authors Linda Fogg, Lawrence Hamilton, and Erin Bell share New Hampshire residents’ responses to questions on the state’s transportation infrastructure in surveys conducted by the University of New Hampshire’s Granite State Poll during ...
Bell, Erin +2 more
core +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
FEBS Open Bio, EarlyView.Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu +10 more
wiley +1 more source
Chimaerins: GAPs that bridge diacylglycerol signalling and the small G-protein Rac [PDF]
, 2007 Chengfeng Yang, M.G. Kazanietz
openalex +1 more source
Early Stages of Homopolymer Collapse
, 1999 Interest in the protein folding problem has motivated a wide range of theoretical and experimental studies of the kinetics of the collapse of flexible homopolymers.
A. Buguin +43 more
core +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source