Results 101 to 110 of about 406,893 (318)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Experimental determination of dynamic allowance for traffic loading in bridges [PDF]
, 2012 Transportation Research Board 89th Annual Meeting, Washington DC, 2010-1-10 to 2010-1-14Bridge codes adopt values for dynamic allowance in traffic load models that are necessarily conservative to cover for an entire range of bridges with different ...
O\u27Brien, Eugene J. +4 more
core
Brazilian Journal of Cardiovascular Surgery, 2015 Myocardial bridging is rare. Myocardial bridges are most commonly localized in the middle segment of the left anterior descending coronary artery. The anatomic features of the bridges vary significantly. Alterations of the endothelial morphology and the vasoactive agents impact on the progression of atherosclerosis of myocardial bridging.
openaire +5 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Optimum design of composite prestressed concrete girder railway bridges [PDF]
, 2012 This paper deals with the formulation of design optimisation of pretsressed concrete bridges. The bridge is of a slab-on-girder type, hence modeled as an equivalent orthotropic plate.
Mohammed, S, Mohammad, F, Al-Nuaimi, A
core
Analysis of Out-Of-Plane Stability of Bow-String Arches
Communications, 2016 Several arch bridge superstructures, designed by the authors of the paper, are presented and analysed. Spatial FEM models were utilised to analyse behaviour of each bridge.
Josef Vican +2 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
The use of micro-simulation for congested traffic load modelling of medium- and long-span bridges [PDF]
, 2011 This paper presents a new approach to the modelling of congested traffic loading events on long span bridges. Conventional traffic load models are based on weigh-in-motion data of non-congested traffic, or something similar to a Poisson Arrival process ...
O\u27Brien, Eugene J. +3 more
core +1 more source
Mechanical modelling and application of vibroacoustic isolators in railway tracks
MATEC Web of Conferences, 2017 The paper presents systematization and description of vibroacoustic isolators used in railway tracks (due to track structure type), with special attention paid to resilient mats.
Zbiciak Artur +4 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source