Results 101 to 110 of about 507,526 (293)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Mechanical modelling and application of vibroacoustic isolators in railway tracks

MATEC Web of Conferences, 2017
The paper presents systematization and description of vibroacoustic isolators used in railway tracks (due to track structure type), with special attention paid to resilient mats.
Zbiciak Artur, Kraśkiewicz Cezary, Oleksiewicz Wojciech, Płudowska-Zagrajek Monika, Lipko Cezary   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Methodologies for Assessing Bridge Performance Under Seismic Action

Romanian Journal of Transport Infrastructure
This paper analyses the seismic response of four continuous precast prestressed concrete girder bridges, with total lengths ranging from 80 m to 200 m, representative of Romanian road infrastructure.
Vlad-Mihai Șimon, Ionuț-Radu Răcănel, Daniel Urdăreanu Vlad   +2 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Comparative Aspects Regarding the Behavior of Fiberglass and Steel Reinforcement in Bridge Beams

Romanian Journal of Transport Infrastructure
This study investigates the feasibility of employing fiberglass reinforcement as a substitute for conventional steel reinforcement in concrete bridge beams, with particular attention to mechanical performance and chemical stability within the alkaline ...
Marin Amăreanu, Ionuț-Radu Răcănel, Octavian Mazilu Claudiu, Constantin-Dorinel Voinițchi, George-Mădălin Pirontea   +4 more
doaj   +1 more source

Theoretical and Experimental Analysis of Stability Limits of Non-Axisymmetric Liquid Bridges under Microgravity Conditions [PDF]

, 1995
The stability of nonaxisymmetric liquid bridges under microgravity conditions is investigated. The influence on the stability of an almost cylindrical liquid bridge of axisymmetric effects like its volume, a small axial acceleration acting on it, and ...
Meseguer Ruiz, José, Rodríguez de Francisco, Pablo, Perales Perales, José Manuel, Bezdenejnykh, N.A.   +3 more
core  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

ASSESSING WITH WEB-BASED TECHNOLOGIES THE SPACE SIGHT CAPABILITY OF THE STUDENTS

Journal of Industrial Design and Engineering Graphics, 2017
Mental Cutting Test (MCT) is a multiple-choice test consisting in mentally cutting 26 solids. For every problem, five answers were provided and learners had to identify the only one correct answer and to mark it. This paper presents the implementation of
NERISANU Raluca, VASILACHE Cosmin, DRAGAN Delia   +2 more
doaj  

Analysis of Out-Of-Plane Stability of Bow-String Arches

Communications, 2016
Several arch bridge superstructures, designed by the authors of the paper, are presented and analysed. Spatial FEM models were utilised to analyse behaviour of each bridge.
Josef Vican, Jaroslav Odrobinak, Jozef Gocal   +2 more
doaj   +1 more source