Results 61 to 70 of about 1,623,523 (364)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Meeting notice for Lavender Bridges advocates for gay awareness
, 2021 The February 12, 1987 issue of the Western Carolinian includes a meeting notice for Lavender Bridges Advocates for Gay Awareness. Lavender Bridges, an anonymously founded student organization open to all individuals, aimed to promote awareness of lesbian
Lavender Bridges;
core
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
A Review of the Network Arch Bridge
Applied Sciences, 2023 The network arch bridge (NAB) is a new structural form of arch bridge that was devised 60 years ago by the Norwegian engineer Per Tveit, who is now prof. dr. docent emeritus at the University of Agder, Norway.
Alexandra Denisa Danciu +5 more
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Comparative structural response of two steel bridges constructed 100 years apart
, 2011 This paper presents a comparative numerical analysis of the structural behaviour and seismic performance of two existing steel bridges, the Infiernillo II Bridge and the Pinhao Bridge, one located in Mexico and the other in Portugal. The two bridges have
Aníbal Costa +17 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Slovak Journal of Civil Engineering, 2017 This paper focuses on the causes and consequences of early-age cracking of mass concrete foundation slabs due to restrained volume changes. Considering the importance of water leaking through cracks in terms of the serviceability, durability and ...
Bilčík Juraj +2 more
doaj +1 more source
Studia Geotechnica et Mechanica, 2021 Waste tyre-derived products, including whole tyres, tyre bales, shreds, chips and crumb rubber, have been widely used in geotechnical applications.
Duda Aleksander, Siwowski Tomasz
doaj +1 more source