Results 91 to 100 of about 545,733 (311)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Enhanced removal of nano-oil droplets utilizing polysilicate aluminum ferric (PSAF): Leveraging bridging and non-polar surface advantages

Water Science and Technology
Hydraulic oil leaks during mechanical maintenance, resulting in flushing wastewater contaminated with dispersed nano-oil droplets. In this study, 75 mg L−1 of polysilicate aluminum ferric (PSAF) was stirred at 350 rpm and the optimal chemical oxygen ...
Yadan Liu, Yanjun Zhou, Hui Su, Chao Gu, Botao Shangguan, Zhiyang Yan, Jinyi Qin   +6 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Limitations of Transversus Abdominis Release (TAR)—Additional Bridging of the Posterior Layer And/Or Anterior Fascia Is the Preferred Solution in Our Clinical Routine If Primary Closure is Not Possible

Journal of Abdominal Wall Surgery
Background: By separating the abdominal wall, transversus abdominis release (TAR) permits reconstruction of the abdominal wall and the placement of large mesh for many types of hernias.
Hartwig Riediger, Ferdinand Köckerling
doaj   +1 more source

Bridging.

, 2013
Bridging.
Abdul Halim Mokhtar (294639), Nader Rahnama (294641), Abdolhamid Daneshjoo (294638), Ashril Yusof (294643)   +3 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

XSEDE Campus Bridging Use Cases L3 Architectural Response

, 2016
This document is the Level 3 Architectural response to the Campus Bridging Use Cases.Submitted by Janet Brown (brown@psc.edu) on 2016-05-09T18:32:11Z No.

core  

Bridging-induced phase separation induced by cohesin SMC protein complexes.

, 2021
Structural maintenance of chromosome (SMC) protein complexes are able to extrude DNA loops. While loop extrusion constitutes a fundamental building block of chromosomes, other factors may be equally important.
Ralph de Groot (10154087), Céline Bouchoux (8961677), Cees Dekker (9066), Frank Uhlmann (54006), Hon Wing Liu (8961674), Andrea Bonato (10154093), Allard J Katan (10154090), Davide Marenduzzo (419988), Masashi Minamino (8136801), Davide Michieletto (1311459), Je-Kyung Ryu (10154084), Eugene Kim (60939)   +11 more
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Social Capital Heterogeneity: Examining Farmer and Rancher Views About Climate Change Through Their Values and Network Diversity

Agriculture
Agriculture plays a crucial role in discussions about environmental challenges because of its ecological footprint and high vulnerability to environmental shocks.
Michael Carolan
doaj   +1 more source