Non-contact and label-free biomechanical imaging: Stimulated Brillouin microscopy and beyond [PDF]
Frontiers in Physics, 2023 Brillouin microscopy based on spontaneous Brillouin scattering has emerged as a unique elastography technique because of its merit of non-contact, label-free, and high-resolution mechanical imaging of biological cell and tissue.
Chenjun Shi, Hongyuan Zhang, Jitao Zhang
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In vivo assessment of mechanical properties during axolotl development and regeneration using confocal Brillouin microscopy [PDF]
Open Biology, 2022 In processes such as development and regeneration, where large cellular and tissue rearrangements occur, cell fate and behaviour are strongly influenced by tissue mechanics.
Camilo Riquelme-Guzmán +7 more
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Mechanical mapping of mammalian follicle development using Brillouin microscopy [PDF]
Communications Biology, 2021 Chan et al. apply Brillouin microscopy to study changes in tissue material properties during mammalian follicle development. Focusing on the Brillouin loss tangent which is independent of the refractive index and mass density, they find that mammalian ...
Chii Jou Chan +2 more
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Measuring mechanical anisotropy of the cornea with Brillouin microscopy [PDF]
Nature Communications, 2022 Here, Brillouin optical microscopy noninvasively visualizes microscale anisotropy of the porcine cornea owing to its lamellar fiber structure and quantifies the longitudinal moduli of the bulk tissue.
Amira M. Eltony +2 more
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A 3D Brillouin microscopy dataset of the in-vivo zebrafish eye [PDF]
Data in Brief, 2020 In this work we present three-dimensional (3D) measurements of Brillouin scattering spectra of the in-vivo zebrafish larvae eye. This dataset was obtained by Brillouin microscopy, an emerging all-optical and non-contact technique that gives access to ...
Héctor Sánchez-Iranzo +3 more
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Stabilized real-time Brillouin microscopy reveals fractal organization of protein condensates in living cells [PDF]
Nature CommunicationsMechanical alterations of protein condensates are increasingly recognized in the etiology of several neurodegenerative diseases, yet their characterization remains technically challenging.
Claudia Testi +14 more
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Brillouin microscopy monitors rapid responses in subcellular compartments [PDF]
PhotoniXMeasurements and imaging of the mechanical response of biological cells are critical for understanding the mechanisms of many diseases, and for fundamental studies of energy, signal and force transduction.
Zachary N. Coker +6 more
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Cellular mechanical properties in response to environmental viscosity imaged by Brillouin Microscopy [PDF]
Communications BiologyAn increasing body of research in biomechanics has revealed that the stiffness of the surrounding environment influences cells fate and function. In this context, a recent study showed that cells exposed to highly viscous fluids migrated and spread ...
Chenchen Handler +5 more
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Brillouin Microscopy of Breast tumor Spheroids On‐a‐Chip: Mechanical and Transcriptional Responses to Microfluidic‐Induced Rapid Deformations [PDF]
Advanced SciencePioneering a novel integrated photonic platform, Brillouin–Raman Microspectroscopy on‐a‐Chip is presented, which enables real‐time, high resolution analysis of mechano‐chemical dynamics in complex 3D biological systems under controlled deformation.
Mona Makkieh +22 more
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Improvement of gain and spatial resolution for impulsive stimulated Brillouin scattering microscopy
PhotoacousticsBrillouin microscopy has been widely used in the mechanical imaging of cells and tissues, and the signal-to-noise (SNR) ratio limits the spectral integration time.
Taoran Le, Jiarui Li, Haoyun Wei, Yan Li
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