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Noninvasive Imaging: Brillouin Confocal Microscopy
2018In the past decades, there has been increased awareness that mechanical properties of tissues and cells are closely associated with disease physiology and pathology. Recognizing this importance, Brillouin spectroscopy instrumentation, already utilized in physics and material science, has been adopted for cell and tissue biomechanics.
Miloš, Nikolić +3 more
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Coaxial line scanning Brillouin microscopy
Optical Elastography and Tissue Biomechanics XIIAbstract Confocal Brillouin microscopy (CBM) enables high-resolution mechanical imaging but has slow acquisition speeds due to its point-by-point scanning strategy. Line-scanning Brillouin microscopy (LSBM) offers imaging acquisition speed improvements but faces challenges such as beam distortion in biaxial configurations and ...
Chenjun Shi, Jitao Zhang
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Three-dimensional Brillouin confocal microscopy
2007 Conference on Lasers and Electro-Optics (CLEO), 2007We present Brillouin confocal microscopy for non-invasively measuring mechanical properties of material with three-dimensional spatial resolution and high sensitivity.
Giuliano Scarcelli, Seok H. Yun
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Brillouin Microscopy for cell and tissue biomechanics
Conference on Lasers and Electro-Optics, 2018We will describe recent progress of Brillouin microscopy, an all-optical imaging modality to map mechanical properties of material based on Brillouin scattering. In ophthalmology, Brillouin microscopy is in clinical trials; at cell level, Brillouin microscopy enables characterization of intracellular elasticity.
Giuliano Scarcelli
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Brillouin Scanning Microscopy in Keratoconus
2016The mechanical properties of the cornea are thought to be central in the development of keratoconus and other corneal ectatic disorders. However, current technologies to measure mechanical properties are limited for in vivo and/or in situ applications. We have recently introduced a new approach, based on optical Brillouin scattering, toward developing ...
Giuliano Scarcelli, Seok Hyun Yun
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Frequency comb Brillouin microscopy
2021Brillouin light scattering (BLS), an almost a century-old technique, has evolved into a powerful and versatile method to study acoustic and magnetic phenomena down to the nanometer size scale. Presently, BLS can be applied in fields as diverse as acoustics, spintronics, geosciences, and biophysics. In addition, the advent of ultrafast laser sources has
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Brillouin microscopy for tissue and cell biomechanics
CLEO: 2015, 2015We have developed an all-optical approach to measure material mechanical properties using Brillouin light scattering. Brillouin imaging uses the elastic modulus as contrast mechanism. We demonstrate its application in vivo for tissue and cellular biomechanics.
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Line-scanning speeds up Brillouin microscopy
Nature Methods, 2023Nargess Khalilgharibi +2 more
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Brillouin Scattering Microscopy for Mechanical Imaging
2015In a world where science is constantly challenged to solve problems of increasing complexity, light is paving new ways to gather information about the physical properties of matter. Among these properties, elasticity is becoming fundamental in the understanding and the diagnosis of several diseases.
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