Results 41 to 50 of about 4,142 (135)

Prophylactic effect of brimonidine to minimize the incidence of subconjunctival hemorrhage in the early postoperative period after 23G pars plana vitrectomy

open access: yesTherapeutic Advances in Ophthalmology, 2021
Background: Several studies have investigated and demonstrated the prophylactic effect of brimonidine drops in preventing subconjunctival hemorrhage in some microincisional ophthalmic surgeries, such as intravitreal injections or cataract surgery ...
Mari Carmen Desco   +7 more
doaj   +1 more source

FeDSNP‐Pa Nanoassemblies: A Triple‐Action Therapeutic Strategy Targeting Oxidative Stress, Inflammation, and Pyroptosis for Retinal Ganglion Cell Protection in Glaucoma

open access: yesAdvanced Functional Materials, Volume 36, Issue 11, 5 February 2026.
FeDSNP‐Pa, a metallized nanoparticle loaded with sodium pyruvate (Pa), exerts triple therapeutic effects by scavenging reactive oxygen species (ROS), suppressing inflammatory responses, and inhibiting pyroptosis signaling pathways. This multifunctional neuroprotective strategy protecting retinal ganglion cells (RGCs) from elevated intraocular pressure ...
Yukun Wu   +5 more
wiley   +1 more source

Implantable Drug Delivery Systems for Skeletal Muscles and Eyes

open access: yesAdvanced NanoBiomed Research, Volume 6, Issue 2, February 2026.
This review highlights the different types of recent implantable drug delivery systems (IDDS) fabricated for a use with skeletal muscles, and with eyes. It presents the developments already made and the current research directions, showing the evolution of IDDS and their great diversity.
Serge Ostrovidov   +8 more
wiley   +1 more source

Pre- and postsynaptic effects of brimonidine on isolated rabbit iris dilator muscles

open access: yesClinical Ophthalmology, 2016
Sonoko Tatsui,1 Hitoshi Ishikawa,2 Kimiya Shimizu,1 Kimiyo Mashimo1 1Department of Ophthalmology, School of Medicine, Kitasato University, 2Department of Orthoptics and Visual Sciences, School of Allied Health Sciences, Kitasato University, Sagamihara ...
Tatsui S   +3 more
doaj  

A validated stability-indicating HPLC method for determination of brimonidine tartrate in BRI/PHEMA drug delivery systems

open access: yesChemistry Central Journal, 2017
Background A simple, rapid and accurate stability-indicating reverse phase high performance liquid chromatography (RP-HPLC) was developed and validated for the determination of brimonidine tartrate in brimonidine tartrate/poly(2-hydroxyethyl methacrylate)
Jianguo Sun, Xiuwen Zhang, Taomin Huang
doaj   +1 more source

Sulphur Analogues of Homoisoflavonoids as Potential Treatments for Neovascular Eye Diseases

open access: yesChemMedChem, Volume 21, Issue 2, January 2026.
Neovascular eye diseases are characterised by the abnormal growth of often fragile blood vessels in the eye. Treatment focuses on reducing angiogenesis as well as reducing oxidative stress induced inflammation, a key underlying cause. Synthetic sulphur analogues of naturally occurring homoisoflavonoids, synthesised in three steps, have shown promise as
Jacob D. Hiles   +9 more
wiley   +1 more source

Mass spectrometry in ocular drug research

open access: yesMass Spectrometry Reviews, Volume 45, Issue 1, Page 37-68, January/February 2026.
Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo   +6 more
wiley   +1 more source

Brimonidine as a possible treatment for myopia

open access: yesBMC Ophthalmology
Background Myopia is becoming a huge burden on the world’s public health systems. The purpose of this study was to explore the effect of brimonidine in the treatment of form-deprivation myopia (FDM) and the relationship between intraocular pressure (IOP)
Zixuan Peng   +8 more
doaj   +1 more source

Bilateral Simultaneous Acute Angle‐Closure Glaucoma Following Over‐the‐Counter Cold Medication

open access: yesCase Reports in Ophthalmological Medicine, Volume 2026, Issue 1, 2026.
Purpose We report a case of bilateral acute angle‐closure glaucoma occurring concurrently after the intake of dextromethorphan, a commonly used over‐the‐counter medication for flu symptom relief. Case Presentation A 65‐year‐old woman presented with bilateral acute angle‐closure glaucoma following 5 days of treatment with an OTC medication.
Chiara Vivarelli   +7 more
wiley   +1 more source

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